慢性精神分裂症患者血小板单胺氧化酶的一些动力学参数
Some kinetic parameters of platelet monoamine oxidase in chronic schizophrenia.
作者信息
Kobes R D, Potkin S G, Wise C D, Bridge T P, Neckers L M, Wyatt R J
出版信息
Psychiatry Res. 1979 Oct;1(2):179-85. doi: 10.1016/0165-1781(79)90059-3.
PMID:298347
Abstract
The michaelis constants (Vmax and Km) for platelet monoamine oxidase (MAO) with tyramine as substrate are found to be significantly lower in chronic schizophrenic patients than in normal controls. Furthermore, these kinetic parameters for the MAO of paranoid chronic schizophrenics are significantly lower than those for nonparanoid chronic schizophrenics. Paranoid chronic schizophrenia may be a separate biochemical disorder from other chronic schizophrenias.
摘要
以酪胺为底物时，发现慢性精神分裂症患者血小板单胺氧化酶（MAO）的米氏常数（Vmax和Km）显著低于正常对照组。此外，偏执型慢性精神分裂症患者MAO的这些动力学参数显著低于非偏执型慢性精神分裂症患者。偏执型慢性精神分裂症可能是一种与其他慢性精神分裂症不同的生化紊乱疾病。
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