Baber N, Halliday L, Littler T, Orme M, Sibeon R G, Chan K
Scand J Rheumatol. 1980;9(1):52-4.
Twenty-one patients with rheumatoid arthritis were given indomethacin 25 mg t.i.d. by mouth for 3 weeks followed by indomethacin 25 mg t.i.d. plus a 100 mg suppository at night, after a 5-day period on placebo capsules. The mean (+/- S.E.) 24-hour creatinine clearance was 57.8 +/- 5.7 ml/min in the placebo period and was not significantly altered during indomethacin therapy, 53.1 +/- 5.5 ml/min in the oral period and 56.6 +/- 6.4 ml/min in the oral plus suppository period (P greater than 0.1). In 6 volunteers, duplicate 2-hour creatinine clearances were performed after a single oral dose of 50 mg indomethacin. After placebo capsules the mean creatinine clearance was 133.7 +/- 9.5 ml/min and after 50 mg indomethacin it was 126.5 +/- 8.9 ml/min (P greater than 0.1). In 4 of the volunteers the mean creatinine clearance after 8 days on indomethacin 25 mg q.i.d. was 117.1+/- 5.3 ml/min (P greater than 0.1). Indomethacin plasma concentrations were in the usual range for the dose given. Indomethacin caused no reduction in the creatinine clearance in spite of causing significant inhibition of prostaglandin E synthesis.
21例类风湿性关节炎患者口服消炎痛，25毫克，每日3次，共3周，之后在服用5天安慰剂胶囊后，改为口服消炎痛25毫克，每日3次，外加每晚1粒100毫克栓剂。安慰剂阶段24小时肌酐清除率的均值（±标准误）为57.8±5.7毫升/分钟，消炎痛治疗期间无显著变化，口服阶段为53.1±5.5毫升/分钟，口服加栓剂阶段为56.6±6.4毫升/分钟（P>0.1）。6名志愿者单次口服50毫克消炎痛后，进行了两次2小时肌酐清除率测定。服用安慰剂胶囊后肌酐清除率均值为133.7±9.5毫升/分钟，服用50毫克消炎痛后为126.5±8.9毫升/分钟（P>0.1）。4名志愿者每日4次服用25毫克消炎痛8天后，肌酐清除率均值为117.1±5.3毫升/分钟（P>0.1）。消炎痛血浆浓度处于给药剂量的正常范围内。尽管消炎痛对前列腺素E合成有显著抑制作用，但并未降低肌酐清除率。
