肝细胞中存在免疫球蛋白A胆汁分泌的囊泡转运机制的证据。
Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A.
作者信息
Renston R H, Jones A L, Christiansen W D, Hradek G T, Underdown B J
出版信息
Science. 1980 Jun 13;208(4449):1276-8. doi: 10.1126/science.7375938.
PMID:7375938
Abstract
Quantitative electron microscopic autoradiography and diaminobenzidine cytochemistry provide evidence for an uptake and vesicular transport mechanism for iodine-125-labeled immunoglobulin A from plasma to bile by hepatocytes in vivo. The data confirm the existence of a hepatobiliary pathway for secretion of immunoglobulin A into the intestine and are consistent with a vesicular transport mechanism for biliary proteins within liver parenchymal cells.
摘要
定量电子显微镜放射自显影术和二氨基联苯胺细胞化学为体内肝细胞将125碘标记的免疫球蛋白A从血浆摄取并通过囊泡转运至胆汁提供了证据。这些数据证实了免疫球蛋白A分泌入肠道的肝胆途径的存在，并且与肝实质细胞内胆汁蛋白的囊泡转运机制一致。
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