Krutovskikh V A
Vopr Onkol. 1980;26(4):93-8.
Female mice of lines TBA, C57BL/6, BALB/c, and hydrids F1 (CBAxC57BL/6) were given 1,2-dimethylhydrazine (DMH) in a dose of 16 mg/kg 20 times weekly. Mice of line BALB/c proved to be mostly sensitive to a carcinogenic effect of DMH (the most low survival rate, the appearance of tumors in the anal region 5 weeks earlier, and much greater probability of their occurrence compared with other lines, extensive tumor invasion of the large intestine). The most low sensitivity to a carcinogenic action of DMH was noted in mice of line C57BL/6. It was found possible to induce uterine sarcomas by DMH in hybrids F1 (CBAxC57BI/6) in a comparatively high per cent of cases (15.4%). Morphological changes in the liver were noted in DMH exposed mice of all lines (dystrophy, cystic cavities, the outgrowth of bile ducts and the connective tissue), which were mostly pronounced in mice of line C57BL/6 (in one case it was adenocarcinoma). The genetic factor is suggested to be of certain importance in the sensitivity to DMH carcinogenic effect.
将TBA、C57BL/6、BALB/c品系的雌性小鼠以及杂交F1代（CBAxC57BL/6）小鼠，每周20次给予剂量为16mg/kg的1,2 - 二甲基肼（DMH）。结果证明，BALB/c品系的小鼠对DMH的致癌作用最为敏感（存活率最低，肛门区域肿瘤比其他品系小鼠提前5周出现，且发生概率远高于其他品系，大肠肿瘤浸润广泛）。C57BL/6品系的小鼠对DMH致癌作用的敏感性最低。发现DMH在较高比例（15.4%）的杂交F1代（CBAxC57BI/6）小鼠中可诱发子宫肉瘤。在所有品系接触DMH的小鼠中均观察到肝脏的形态学变化（营养不良、囊腔、胆管和结缔组织增生），其中C57BL/6品系小鼠的变化最为明显（有一例为腺癌）。遗传因素被认为在对DMH致癌作用的敏感性方面具有一定重要性。
