Parfenov Iu D, Nikonova T V, Montesano R, Politova S N, Turusov V S
Eksp Onkol. 1987;9(5):56-60.
The (CBA x C57Bl)F1 female mice were treated with weekly injections of 1,2-dimethylhydrazine (DMH) at a dose rate of 4.15 mg/kg of body weight during different time periods. Relations between the incidence of organ specified particular tumours depend on the total DMH dose. Incidence of haemoblastoses decreases with an increase in the DMH dose. Dose relationships of the tumour incidence are analyzed statistically by the method with intercurrent mortality corrections and carcinogen effect expressed by relations of the observed and expected numbers.
在不同时间段，对（CBA×C57Bl）F1雌性小鼠每周注射1,2 - 二甲基肼（DMH），剂量率为4.15毫克/千克体重。特定器官肿瘤的发生率之间的关系取决于DMH的总剂量。成血病的发生率随DMH剂量的增加而降低。采用并发死亡率校正方法对肿瘤发生率的剂量关系进行统计学分析，并通过观察值与预期值的关系来表示致癌物效应。
