Kralios F A, Millar C K
Cardiovasc Res. 1978 Sep;12(9):547-54. doi: 10.1093/cvr/12.9.547.
The functional development of cardiac sympathetic nerves was investigated in 52 puppies, 1 to 6 weeks of age. The effect of nerve stimulation on refractory period shortening at eight epicardial sites was used as criterion. Zero or minimal effect was observed at the first week of life for all the nerves tested, then a sharp increase of effect was observed at the second week, while at the third week, an unexpected decrease was observed for all nerves. At the fourth week, the effect increased again and remained high for the subsequent weeks. Thus functional sympathetic innervation of the heart is not complete at birth, but continues to develop throughout the first 6 weeks of life, following an irregular pattern of progression. The nonuniform maturation of cardiac nerves coupled with the localised distribution of the nerves may provide a basis for regional sympathetic imbalance and subsequent arrhythmiogenesis in early life.
对52只1至6周龄的幼犬的心脏交感神经功能发育进行了研究。以神经刺激对八个心外膜部位不应期缩短的影响作为标准。在出生后的第一周，所有测试神经均观察到零效应或最小效应，然后在第二周观察到效应急剧增加，而在第三周，所有神经均出现意外下降。在第四周，效应再次增加，并在随后几周保持高位。因此，心脏的功能性交感神经支配在出生时并不完整，而是在生命的前6周内持续发育，遵循不规则的进展模式。心脏神经的不均匀成熟以及神经的局部分布可能为早期生命中的区域交感神经失衡和随后的心律失常发生提供基础。
