Donnadieu M, Schimpff R M, Garnier P, Chaussain J L, Job J C
Acta Endocrinol (Copenh). 1980 Feb;93(2):134-8. doi: 10.1530/acta.0.0930134.
Since transferrin (Tf) in vitro has a growth-promoting activity and is associated with NSILA properties, the aim of this work was to study in vivo the relationships between Tf, somatomedin activity (SM), growth hormone (GH) secretion, and height velocity in children. An iv infusion of ornithine hydrochloride was given to 23 controls; the induced rise of GH was accompanied by a simultaneous fall of SM (r = -0.711, P less than 0.001) and was preceded by a fall of Tf (r = -0.610, P less than 0.01). In 17 obese children SM was within the normal range, when Tf levels were higher and arginine-induced GH peaks lower than in the controls, and a negative correlation was found between Tf basal levels and GH peaks (r = -0.608, P less than 0.01). In 9 children with confirmed hypopituitarism the Tf levels were significantly lower than in the controls. In 14 children with confirmed or suspected hypopituitarism a single im injection of hGH (6 mg) failed to induce Tf variations over 24 h. In 39 of these children the height velocity was significantly correlated with Tf basal levels (r = 0.701, P less than 0.001). These data suggest that transferrin is involved in growth regulation, and that GH secretion is related to transferrin levels by a feed-back mechanism.
由于转铁蛋白（Tf）在体外具有促进生长的活性且与非抑制胰岛素样活性物质（NSILA）特性相关，本研究的目的是在体内研究儿童体内Tf、生长调节素活性（SM）、生长激素（GH）分泌与身高增长速度之间的关系。对23名对照组儿童静脉输注盐酸鸟氨酸；诱导的GH升高伴随着SM同时下降（r = -0.711，P < 0.001），且在下降之前Tf也下降（r = -0.610，P < 0.01）。在17名肥胖儿童中，SM在正常范围内，此时Tf水平较高，精氨酸诱导的GH峰值低于对照组，并且发现Tf基础水平与GH峰值之间呈负相关（r = -0.608，P < 0.01）。在9名确诊为垂体功能减退的儿童中，Tf水平明显低于对照组。在14名确诊或疑似垂体功能减退的儿童中，单次肌肉注射hGH（6mg）在24小时内未能诱导Tf变化。在这些儿童中的39名中，身高增长速度与Tf基础水平显著相关（r = 0.701，P < 0.001）。这些数据表明转铁蛋白参与生长调节，并且GH分泌通过反馈机制与转铁蛋白水平相关。
