Herin P, Eriksson M
Acta Paediatr Scand. 1980 May;69(3):315-20. doi: 10.1111/j.1651-2227.1980.tb07085.x.
The purpose of this retrospective study was to investigate the therapeutic value of steroids and cytotoxics in children with idiopathic nephrotic syndrome which developed during the period 1968-1977. Thirty-eight patients were followed. They were divided into three morphological groups based on renal biopsy findings, i.e., minimal changes (MCNS, n = 34), focal segmental glomerulosclerosis (FSGS, n=2) and atypical undefined changes (Undef., n=2). In the latter two groups therapy was less successful than in the MCNS-group. This study conclusively demonstrates that cytotoxic therapy is of value in prolonging the duration of the remission and increasing the responsiveness to steroids in children with MCNS.
这项回顾性研究的目的是调查1968年至1977年期间患特发性肾病综合征儿童使用类固醇和细胞毒性药物的治疗价值。对38名患者进行了随访。根据肾活检结果，将他们分为三个形态学组，即微小病变（MCNS，n = 34）、局灶节段性肾小球硬化（FSGS，n = 2）和非典型未明确病变（未定义，n = 2）。在后两组中，治疗效果不如MCNS组。这项研究确凿地表明，细胞毒性疗法对于延长MCNS患儿的缓解期及提高其对类固醇的反应性具有价值。
