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Cyclophosphamide in treatment of minimal change nephrotic syndrome.

作者信息

Shohet I, Meyerovitch J, Aladjem M, Boichis H

机构信息

Department of Clinical Epidemiology, Chaim Sheba Medical Centre, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel.

出版信息

Eur J Pediatr. 1988 Apr;147(3):239-41. doi: 10.1007/BF00442686.

DOI:10.1007/BF00442686
PMID:3391218
Abstract

Nineteen children with the minimal change form of nephrotic syndrome were divided according to their pattern of response to prednisone: steroid-dependent and frequent relapsers. All patients received cyclophosphamide for 56 days in a single daily dose of 2.5 mg/kg (total 140 mg/kg), in order to prolong the length of remission. The percentage of patients who continued in remission at the end of the 1st, 2nd and 5th years was greater in the frequent-relapser group. This retrospective analysis confirms that the pattern of response to prednisone may be an important criterion for the selection of patients who will benefit from cyclophosphamide therapy.

摘要

相似文献

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引用本文的文献

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Cyclophosphamide in steroid-dependent nephrotic syndrome.环磷酰胺治疗激素依赖型肾病综合征。
Pediatr Nephrol. 2011 Jun;26(6):927-32. doi: 10.1007/s00467-011-1830-0. Epub 2011 Mar 12.
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Long-term results of two unconventional agents in steroid-dependent nephrotic children.

本文引用的文献

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STUDIES ON AN INTERMITTENT CORTICOSTEROID DOSAGE REGIMEN.间歇性皮质类固醇给药方案的研究
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Cytotoxic treatment in children with idiopathic nephrotic syndrome.特发性肾病综合征患儿的细胞毒性治疗。
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Primary nephrotic syndrome in children: clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity. A Report of the International Study of Kidney Disease in Children.
两种非传统药物治疗激素依赖型肾病患儿的长期疗效
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N Engl J Med. 1982 Feb 25;306(8):451-4. doi: 10.1056/NEJM198202253060803.
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Dogma disputed: alternate-day steroid therapy in the nephrotic syndrome of childhood.教条受到质疑：儿童肾病综合征的隔日类固醇疗法。
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Testicular function in prepubertal and pubertal male patients treated with cyclophosphamide for nephrotic syndrome.环磷酰胺治疗肾病综合征的青春期前和青春期男性患者的睾丸功能
J Pediatr. 1974 Jun;84(6):831-6. doi: 10.1016/s0022-3476(74)80758-4.
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Therapeutic and toxic effects observed with different dosage programs of cyclophosphamide in treatment of steroid-responsive but frequently relapsing nephrotic syndrome.
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Lancet. 1970 Sep 5;2(7671):479-82. doi: 10.1016/s0140-6736(70)90108-x.
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Lancet. 1970 Jun 27;1(7661):1353-9. doi: 10.1016/s0140-6736(70)91268-7.