大鼠体内二硝基邻甲酚（DNOC）和二硝基丁酚（DNBP）的肠道代谢

Intestinal metabolism of DNOC and DNBP in the rat.

作者信息

Ingebrigtsen K, Frøslie A

出版信息

Acta Pharmacol Toxicol (Copenh). 1980 May;46(5):326-8. doi: 10.1111/j.1600-0773.1980.tb02462.x.

DOI:10.1111/j.1600-0773.1980.tb02462.x

Abstract

The metabolism of the dinitrophenols DNOC and DNBP and their respective monoamino derivatives, 6-ANOC and 6-ANBP, was studied in rat caecal incubates. All of the compounds were reduced to their corresponding diamino metabolites. The results are discussed in relation to the comparative toxicology of the dinitrophenols with special regard to a possible significance of the intestinal metabolites.

摘要

在大鼠盲肠培养液中研究了二硝基酚DNOC和DNBP及其各自的单氨基衍生物6 - ANOC和6 - ANBP的代谢情况。所有化合物均被还原为其相应的二氨基代谢产物。结合二硝基酚的比较毒理学对结果进行了讨论，特别关注肠道代谢产物的可能意义。