Chodera A, Cenajek D, Wójciak Z, Szczawiínska K, Kozaryn I
Acta Physiol Pol. 1980 Jan-Feb;31(1):41-6.
Investigations were carried out for elucidating the effect of cystamine on the metabolism of imipramine in rats irradiated with a dose of 600 R. The investigations were based on determination of desmethylimipramine, the principal metabolite of this drug. It was found that cystamine reduced the serum imipramine level to control values but had no effect decreasing the level of desmethylimipramine. It caused also no fall in the concentration of this metabolite in brain tissue and even it raised this concentration. The authors explained these findings as a result of secondary resorption of desmethylimipramine into the blood stream, and a result of changed activity of beta-glucuronidase, these mechanisms being partly responsible for the overall effect.
开展了多项研究以阐明胱胺对接受600伦琴剂量照射的大鼠体内丙咪嗪代谢的影响。这些研究基于对该药物主要代谢产物去甲丙咪嗪的测定。结果发现，胱胺可将血清丙咪嗪水平降至对照值，但对降低去甲丙咪嗪水平没有作用。它也未导致脑组织中该代谢产物浓度下降，甚至还使其浓度升高。作者将这些发现解释为去甲丙咪嗪二次吸收入血流的结果，以及β-葡萄糖醛酸酶活性改变的结果，这些机制部分导致了总体效应。
