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氨甲环酸预防自发性蛛网膜下腔出血复发

Prevention of recurrence of spontaneous subarachnoid haemorrhage by tranexamic acid.

作者信息

Gelmers H J

出版信息

Acta Neurochir (Wien). 1980;52(1-2):45-50. doi: 10.1007/BF01400945.

DOI:10.1007/BF01400945
PMID:7376944
Abstract

Tranexamic acid as an antifibrinolytic agent has been investigated in a controlled study in patients with recent subarachnoid haemorrhage. It is concluded that tranexamic acid improves neither rebleeding rates, nor mortality. Predominantly thrombotic complications have been noted as a more serious side effect of tranexamic acid.

摘要

在一项针对近期蛛网膜下腔出血患者的对照研究中，对氨甲环酸作为一种抗纤溶药物进行了调查。得出的结论是，氨甲环酸既不能降低再出血率，也不能降低死亡率。已注意到主要的血栓形成并发症是氨甲环酸更严重的副作用。

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1
Prevention of recurrence of spontaneous subarachnoid haemorrhage by tranexamic acid.氨甲环酸预防自发性蛛网膜下腔出血复发
Acta Neurochir (Wien). 1980;52(1-2):45-50. doi: 10.1007/BF01400945.
2
Comparative clinical trial of epsilon amino-caproic acid and tranexamic acid in the prevention of early recurrence of subarachnoid haemorrhage.ε-氨基己酸与氨甲环酸预防蛛网膜下腔出血早期复发的比较临床试验
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3
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Stroke. 1979 Sep-Oct;10(5):519-22. doi: 10.1161/01.str.10.5.519.

引用本文的文献

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Front Neurol. 2025 Jun 17;16:1617817. doi: 10.3389/fneur.2025.1617817. eCollection 2025.
2
The efficacy of antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.抗纤维蛋白溶解疗法在动脉瘤性蛛网膜下腔出血中的疗效：一项系统评价和荟萃分析。
Future Sci OA. 2023 May 16;9(6):FSO866. doi: 10.2144/fsoa-2023-0014. eCollection 2023 Jul.
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Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage.

本文引用的文献

1
Thrombotic state after a hemorrhagic diathesis, a possible complication of therapy with epsilon-aminocapproic acid.出血素质后的血栓形成状态，ε-氨基己酸治疗的一种可能并发症。
Blood. 1962 Jun;19:694-701.
2
xi-Aminocaproic acid: an inhibitor of plasminogen activation.ε-氨基己酸：一种纤溶酶原激活抑制剂。
J Biol Chem. 1959 Apr;234(4):832-7.
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[Rapid physiological coagulation method in determination of fibrinogen].[快速生理凝血法测定纤维蛋白原]
抗纤维蛋白溶解疗法治疗颅内动脉瘤性蛛网膜下腔出血。
Cochrane Database Syst Rev. 2022 Nov 9;11(11):CD001245. doi: 10.1002/14651858.CD001245.pub3.
4
Tranexamic acid in non-traumatic intracranial bleeding: a systematic review and meta-analysis.氨甲环酸用于非创伤性颅内出血：一项系统评价与荟萃分析
Sci Rep. 2021 Jul 27;11(1):15275. doi: 10.1038/s41598-021-94727-y.
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Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage.动脉瘤性蛛网膜下腔出血的抗纤溶治疗
Cochrane Database Syst Rev. 2013 Aug 30;2013(8):CD001245. doi: 10.1002/14651858.CD001245.pub2.
6
Antifibrinolytic therapy to prevent early rebleeding after subarachnoid hemorrhage.抗纤维蛋白溶解疗法预防蛛网膜下腔出血后早期再出血
Neurocrit Care. 2008;8(3):418-26. doi: 10.1007/s12028-008-9088-5.
7
Tranexamic acid: a review of its use in surgery and other indications.氨甲环酸：其在手术及其他适应症中的应用综述
Drugs. 1999 Jun;57(6):1005-32. doi: 10.2165/00003495-199957060-00017.
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Letter to the editors of acta neurochirurgica. Management of patients with subarachnoid haemorrhage with tranexamic acid.
Acta Neurochir (Wien). 1980;54(1-2):127-31. doi: 10.1007/BF01401951.
9
Antifibrinolytic treatment in subarachnoid haemorrhage: present state.蛛网膜下腔出血的抗纤溶治疗：现状
Acta Neurochir (Wien). 1982;63(1-4):233-44. doi: 10.1007/BF01728877.
10
Comparative clinical trial of epsilon amino-caproic acid and tranexamic acid in the prevention of early recurrence of subarachnoid haemorrhage.ε-氨基己酸与氨甲环酸预防蛛网膜下腔出血早期复发的比较临床试验
J Neurol Neurosurg Psychiatry. 1981 Sep;44(9):810-3. doi: 10.1136/jnnp.44.9.810.
Acta Haematol. 1957 Apr;17(4):237-46. doi: 10.1159/000205234.
4
Hypothermia, and interruption of carotid, or carotid and vertebral circulation, in the surgical management of intracranial aneurysms.低温以及在颅内动脉瘤手术治疗中阻断颈动脉或颈动脉与椎动脉循环。
J Neurosurg. 1956 Jan;13(1):1-42. doi: 10.3171/jns.1956.13.1.0001.
5
Natural history of subarachnoid hemorrhage, intracranial aneurysms and arteriovenous malformations.蛛网膜下腔出血、颅内动脉瘤和动静脉畸形的自然病史。
J Neurosurg. 1966 Sep;25(3):321-68. doi: 10.3171/jns.1966.25.3.0321.
6
A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum.一种用于检测人血清中纤维蛋白溶解分裂产物的快速、简单、灵敏的方法。
Proc Soc Exp Biol Med. 1969 Jul;131(3):871-5. doi: 10.3181/00379727-131-33998.
7
The use of antifibrinolytic substances in ruptured intracranial aneurysms.抗纤维蛋白溶解物质在颅内破裂动脉瘤中的应用。
Neurochirurgia (Stuttg). 1969 May;12(3):100-2. doi: 10.1055/s-0028-1095290.
8
Glomerular capillary thrombosis and acute renal failure after epsilon-amino caproic acid therapy.ε-氨基己酸治疗后出现肾小球毛细血管血栓形成及急性肾衰竭。
N Engl J Med. 1969 May 15;280(20):1102-4. doi: 10.1056/NEJM196905152802006.
9
Antifibrinolytic therapy for intracranial aneurysms.颅内动脉瘤的抗纤溶治疗。
J Neurosurg. 1968 Jan;28(1):21-3. doi: 10.3171/jns.1968.28.1.0021.
10
Thrombosis with epsilon aminocaproic acid therapy.使用ε-氨基己酸治疗导致的血栓形成。
Am J Clin Pathol. 1971 Aug;56(2):151-4. doi: 10.1093/ajcp/56.2.151.