Wilkinson E J, Hause L L, Sasse E A, Pattillo R A, Milbrath J R, Lewis J D
Am J Clin Pathol. 1980 May;73(5):669-75. doi: 10.1093/ajcp/73.5.669.
A prospective study of 123 patients was undertaken to determine whether carcinoembryonic antigen (CEA) or L-fucose could be used as "tumor markers" to distinguish patients who had mammary cancer (41) from patients who had benign mammary disease (41) and patients who did not have mammary cancer (41). The predictive value of positive test results for both L-fucose and CEA was lower for patients who smoked than for those who did not. The sensitivities of CEA and L-fucose indicators are both below 55%. There were frequent false-positive and false-negative results. A substantial overlap in the levels of CEA and L-fucose was found for the patients who had mammary cancer and those who had benign mammary disease. CEA and L-fucose performed similarly in distinguishing cancer from benign disease. For patients who smoked, however, the predictive value of L-fucose was only 44%. The effect of smoking on L-fucose levels may account for discrepancies in L-fucose data reported in previous studies of mammary cancer. Neither CEA nor L-fucose were found to be of value in screening for mammary cancer.
对123例患者进行了一项前瞻性研究，以确定癌胚抗原（CEA）或L-岩藻糖是否可作为“肿瘤标志物”，用于区分患有乳腺癌的患者（41例）、患有乳腺良性疾病的患者（41例）和未患乳腺癌的患者（41例）。吸烟患者中L-岩藻糖和CEA检测结果呈阳性的预测价值低于不吸烟患者。CEA和L-岩藻糖指标的敏感性均低于55%。假阳性和假阴性结果频繁出现。发现患有乳腺癌的患者和患有乳腺良性疾病的患者的CEA和L-岩藻糖水平存在大量重叠。CEA和L-岩藻糖在区分癌症和良性疾病方面表现相似。然而，对于吸烟患者，L-岩藻糖的预测价值仅为44%。吸烟对L-岩藻糖水平的影响可能是先前乳腺癌研究中L-岩藻糖数据存在差异的原因。未发现CEA和L-岩藻糖在乳腺癌筛查中有价值。
