Misra P S, Evanov F A, Wessely Z, Rosenblum G A, Singh P
Am J Gastroenterol. 1980 Jan;73(1):54-9.
An atypical case of idiopathic cholestasis of pregnancy occurring in the 16th week of gestation in a 24-year old Pakistani female is presented. The case is unusual both in the duration of the jaundice as well as in the high levels of bilirubin found in the presence of normal renal function. A review of the recent literature emphasizes that this disorder is not entirely benign for the mother and the fetus. It also discusses some of the alterations in estrogen and lipid metabolism that are seen, as well as the possible mechanisms responsible for the increased incidence of gallstone formation found in these patients.
本文介绍了一名24岁巴基斯坦女性在妊娠第16周时发生的特发性妊娠胆汁淤积症的非典型病例。该病例在黄疸持续时间以及肾功能正常情况下胆红素水平升高方面均较为罕见。近期文献综述强调，这种疾病对母亲和胎儿并非完全无害。文中还讨论了所观察到的雌激素和脂质代谢的一些变化，以及这些患者胆结石形成发生率增加的可能机制。
