Alexander N, Velasquez M T, Decuir M, Maronde R F
Am J Physiol. 1980 Apr;238(4):H521-6. doi: 10.1152/ajpheart.1980.238.4.H521.
Blood pressure and circulating levels of norepinephrine (NE), epinephrine (Epi), and dopamine-beta-hydroxylase (DBH) were measured sequentially in sinoaortic-denervated (SAD) Wistar rats and in sham-operated (SO) rats. Systolic tail pressure, plasma NE and E, and plasma DBH all increased significantly within 2 days in SAD rats. In separate studies of rats with indwelling arterial catheters, arterial pressure and plasma NE and DBH were increased in SAD rats in home cages; restraint caused similar increases of pressure and catecholamines in both groups. Systolic pressure remained increased up to 4 mo and plasma DBH for 10 wk in SAD rats; plasma NE and E, however, declined by 3 wk and thereafter remained close to values of SO rats. Additionally, DBH was increased in heart, mesenteric blood vessels and adrenal glands of SAD rats up to 6 wk; tissue monoamine oxidase activity was also increased up to 4 mo. These findings suggest that activation of the sympathetic nervous system initiates and probably sustains hypertension in SAD rats up to 6 wk after operation; thereafter some other mechanism(s) sustains the hypertension.
对去窦主动脉神经支配（SAD）的Wistar大鼠和假手术（SO）大鼠依次测量血压以及去甲肾上腺素（NE）、肾上腺素（Epi）和多巴胺-β-羟化酶（DBH）的循环水平。SAD大鼠的收缩期尾动脉压、血浆NE和E以及血浆DBH在2天内均显著升高。在对留置动脉导管的大鼠进行的单独研究中，SAD大鼠在饲养笼中的动脉压、血浆NE和DBH升高；束缚使两组的血压和儿茶酚胺出现类似升高。SAD大鼠的收缩压在长达4个月的时间内持续升高，血浆DBH在10周内持续升高；然而，血浆NE和E在3周后下降，此后一直接近SO大鼠的值。此外，SAD大鼠心脏、肠系膜血管和肾上腺中的DBH在长达6周的时间内升高；组织单胺氧化酶活性在长达4个月的时间内也升高。这些发现表明，交感神经系统的激活在术后6周内启动并可能维持SAD大鼠的高血压；此后，一些其他机制维持高血压。
