麻醉对自发性高血压大鼠和Wistar-Kyoto大鼠血流动力学的影响。

Anesthetic effects on hemodynamics of spontaneously hypertensive and Wistar-Kyoto rats.

作者信息

Smith T L, Hutchins P M

出版信息

Am J Physiol. 1980 Apr;238(4):H539-44. doi: 10.1152/ajpheart.1980.238.4.H539.

DOI:10.1152/ajpheart.1980.238.4.H539

Abstract

We studied the effects of three anesthetic agents on the central hemodynamics of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats instrumented with chronic electromagnetic flow probes and arterial pressure catheters. Cardiovascular alterations due to ether, pentobarbital sodium (PBS; 50 mg/kg), and a 2% chloralose-7.5% urethan mixture (CU; 6 ml/kg) were determined. Ether produced significant elevations in heart rate (HR), cardiac index (CI), stroke volume (SV), and peak aortic flow velocity (PAFV) in SHRs (P less than 0.01) and elevations of HR and CI in WKYs (P less than 0.05). Ether reduced total peripheral resistance (TPR) and mean arterial pressure (MAP) in WKYs and SHRs (P less than 0.01). PBS decreased HR, CI, SV, MAP, PAFV, and minute work (MW) in both WKYs and SHRs (P less than 0.05--P less than 0.001). PBS also lowered TPR in WKYs (P less than 0.05). CU produced effects similar to those of PBS, but did not alter HR or TPR. Central hemodynamics are therefore significantly altered by these anesthetics when compared to those of conscious rats. These agents also have differential effects on the hemodynamics of SHRs and WKYs.

摘要

我们研究了三种麻醉剂对自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）中心血流动力学的影响，这些大鼠植入了慢性电磁流量探头和动脉压导管。测定了乙醚、戊巴比妥钠（PBS；50mg/kg）和2%水合氯醛-7.5%乌拉坦混合物（CU；6ml/kg）引起的心血管改变。乙醚使SHR的心率（HR）、心脏指数（CI）、每搏量（SV）和主动脉峰值流速（PAFV）显著升高（P<0.01），使WKY的HR和CI升高（P<0.05）。乙醚降低了WKY和SHR的总外周阻力（TPR）和平均动脉压（MAP）（P<0.01）。PBS降低了WKY和SHR的HR、CI、SV、MAP、PAFV和分钟功（MW）（P<0.05 - P<0.001）。PBS还降低了WKY的TPR（P<0.05）。CU产生了与PBS相似的效果，但未改变HR或TPR。因此，与清醒大鼠相比，这些麻醉剂显著改变了中心血流动力学。这些药物对SHR和WKY的血流动力学也有不同的影响。