Jones C E, Mayer L R
Am J Physiol. 1980 Apr;238(4):H569-74. doi: 10.1152/ajpheart.1980.238.4.H569.
Left ventricular contractile force (LVCF), dP/dt, arteriovenous oxygen difference [(a-v)O2], circumflex blood flow (CBF), and myocardial oxygen consumption (MVo2) were determined in dogs during intravenous infusion of inosine at various rates. LCVF and maximal dP/dt increased progressively with increasing infusion rates. CBF increased by 100% at the highest infusion rate, but (a-v)O2 was reduced by 30%. At each infusion rate the increase in MVo2 was only 40% the increase in CBF (P less than 0.05), indicating a nonmetabolically coupled vasodilatation. To further demonstrate this action, the effects of isoproterenol on CBF and (a-v)O2 were compared with those of inosine. During isoproterenol infusion, the increase in CB paralleled the increase in MVo2, and (a-v)O2 showed no change. Intracoronary infusion experiments showed that a 100% increase in flow was caused by an arterial inosine level of about 150 micro M. At inosine levels over 400 micro M, the increase in flow was equal to the maximal increase seen with adenosine infusion.
在以不同速率静脉输注肌苷的过程中，测定了犬的左心室收缩力（LVCF）、dp/dt、动静脉氧差[（a-v）O₂]、回旋支血流量（CBF）和心肌耗氧量（MVo₂）。随着输注速率的增加，LCVF和最大dp/dt逐渐增加。在最高输注速率时，CBF增加了100%，但（a-v）O₂降低了30%。在每个输注速率下，MVo₂的增加仅为CBF增加的40%（P<0.05），表明存在非代谢偶联的血管舒张。为了进一步证明这种作用，将异丙肾上腺素对CBF和（a-v）O₂的影响与肌苷的影响进行了比较。在输注异丙肾上腺素期间，CB的增加与MVo₂的增加平行，且（a-v）O₂无变化。冠状动脉内输注实验表明，动脉肌苷水平约为150μM时可导致血流量增加100%。当肌苷水平超过400μM时，血流量的增加与腺苷输注时所见的最大增加量相当。
