Manning R D, Guyton A C
Am J Physiol. 1980 May;238(5):H645-51. doi: 10.1152/ajpheart.1980.238.5.H645.
The dynamics fluid volume distribution between the blood and interstitium was studied in 24 anephric conscious dogs by making serial measurements of blood volume, sodium space, and plasma proteins during several different states of hydration. After recovery from splenectomy and unilateral nephrectomy, the remaining kidney was removed, and intravenous infusion of lactated Ringer solution equivalent to 5%, 10%, or 20% of the body weight followed the next day. Blood volume and sodium space were elevated in each infusion group for the entire 25-h postinfusion period of measurements, while total amount of circulating proteins increased in the 10% group and decreased in the 20% group, which blunted the increase in blood volume in this group. During the first 5 h after infusion, the increase in blood volume was proportional to the increase in sodium space up to a sodium space of 50% above control. By 24 h postinfusion the relationship between blood volume (BV%) and sodium space (SS%) as percent control was linear over the entire range of sodium spaces (BV% = 68.0 + 0.32 SS%, r = 0.99).
通过在几种不同的水合状态下连续测量血容量、钠分布容积和血浆蛋白，研究了24只去肾清醒犬血液与间质之间的动态液体容量分布。在脾切除和单侧肾切除恢复后，次日切除剩余的肾脏，然后静脉输注相当于体重5%、10%或20%的乳酸林格溶液。在整个25小时的输注后测量期内，每个输注组的血容量和钠分布容积均升高，而循环蛋白总量在10%组增加，在20%组减少，这使该组血容量的增加减弱。在输注后的前5小时内，血容量的增加与钠分布容积的增加成正比，直至钠分布容积比对照高50%。输注后24小时，血容量（BV%）与钠分布容积（SS%）作为对照百分比之间的关系在整个钠分布容积范围内呈线性（BV% = 68.0 + 0.32 SS%，r = 0.99）。
