Sporn P, Steinbereithner K, Sluga E, Linsmayer H, Schenk E
Anaesthesist. 1980 Feb;29(2):85-8.
A case report of a fatal hyperthermic crisis after premedication and before introduction of anaesthesia is given. Based on the typical clinical course, CK isoenzyme patterns and preliminary results of familial investigation the diagnosis of malignant hyperthermia could be established. According to literature reports, psychic stress and/or phenothiazine medication may be assumed as triggering factors. Until a potential causality between malignant hyperthermia and phenothiazine medication can definitely be ruled out, their use in suspicious cases of susceptibility to malignant hyperthermia should be avoided.
本文报告了一例在术前用药后、麻醉诱导前发生致命性高热危象的病例。根据典型的临床病程、肌酸激酶同工酶谱以及家族调查的初步结果，确诊为恶性高热。根据文献报道，精神压力和/或吩噻嗪类药物治疗可能被认为是触发因素。在恶性高热与吩噻嗪类药物治疗之间的潜在因果关系尚未完全排除之前，应避免在可疑的恶性高热易感性病例中使用此类药物。
