Ghandi B, Freye E, Avril G
Anesth Analg (Paris). 1980;37(3-4):127-31.
The use of a vitamin derivate (chlormethiazole) in anaesthesia. Owing to its hypnotic properties and its wide margin of safety, "chlormethiazole" (a derivate of vitamin B1) was used in 30 patients which underwent varying surgical procedures. Since the drug exhibits no analgetic effect, fentanyl was added to maintain a sufficient depth of anesthesia. The patients were artificially ventilated with N2O/O2 at a rate of 3/1. Chlormethiazole, even when used in large doses (2400 mg) over a long period of time (5 hours was well tolerated. The technique therefore offers another opportunity to replace droperidol in classical neuroleptanaesthesia, which is often the cause for uncomfortable neurovegetative side-effects in the post-operative period.
一种维生素衍生物（氯美噻唑）在麻醉中的应用。由于其催眠特性及广泛的安全范围，“氯美噻唑”（维生素B1的一种衍生物）被用于30例接受不同外科手术的患者。由于该药物无镇痛作用，因此添加了芬太尼以维持足够的麻醉深度。患者通过N2O/O2以3/1的比例进行人工通气。氯美噻唑即使长时间大剂量使用（2400毫克，持续5小时）也耐受性良好。因此，该技术为在经典神经安定麻醉中替代氟哌利多提供了另一种选择，氟哌利多常常是术后不适的神经植物性副作用的原因。
