泛影葡胺76对血管导管中血小板功能和血栓形成的抑制作用。

Inhibitory effect of Urografin 76 on platelet function and thrombus formation in vascular catheters.

作者信息

Motomiya T, Yamazaki H

出版信息

Angiology. 1980 Apr;31(4):283-90. doi: 10.1177/000331978003100408.

DOI:10.1177/000331978003100408

Abstract

The effect of Urografin 76 on platelet aggregation and thrombus formation in vascular catheter was studied. In vitro experiments revealed that ADP-, epinephrine-, and collagen-induced platelet aggregation was significantly inhibited by Urografin 76 in concentrations greater than 0.3, 1, and 5% respectively. Rabbits that received 10 ml of Urografin 76 demonstrated a transient decrease in platelet aggregation for at least 3 minutes. Urografin 76 was apparently more effective than saline in preventing blood clot formation.

摘要

研究了泛影葡胺76对血管导管中血小板聚集和血栓形成的影响。体外实验表明，分别在浓度大于0.3%、1%和5%时，泛影葡胺76能显著抑制二磷酸腺苷、肾上腺素和胶原诱导的血小板聚集。接受10毫升泛影葡胺76的兔子血小板聚集至少有3分钟的短暂下降。在预防血凝块形成方面，泛影葡胺76显然比生理盐水更有效。