孕早期服用华法林后出现点状软骨发育不良。病例报告及文献综述

Arch Dis Child. 1980 Feb;55(2):139-42. doi: 10.1136/adc.55.2.139.

A third case of chondrodysplasia punctata after exposure to warfarin alone in early pregnancy is described. The clinical course of the child during the first 18 months is outlined. The use of warfarin in early pregnancy must be avoided because of its established teratogenic effects in causing this syndrome, in addition to an overall increase in perinatal mortality.

本文描述了首例仅在妊娠早期接触华法林后发生点状软骨发育不良的病例。概述了该患儿在出生后18个月内的临床病程。鉴于华法林在导致该综合征方面已明确的致畸作用以及围产期死亡率的总体增加，妊娠早期必须避免使用华法林。