Pettifor J M, Benson R
J Pediatr. 1975 Mar;86(3):459-62. doi: 10.1016/s0022-3476(75)80986-3.
Three small infants whose mothers had received oral anticoagulant therapy during the first trimester of pregnancy are described. These infants all had hypoplasia of the nasal bones, and two had stippling of epiphyses and bones and deformities of the bones of the hand. One child is mentally retarded. It is suggested that these abnormalities may be related to maternal oral anticoagulant therapy during the first trimester.
本文描述了三名母亲在妊娠头三个月接受口服抗凝治疗的小婴儿。这些婴儿均有鼻骨发育不全，两名婴儿有骨骺和骨骼点状钙化以及手部骨骼畸形。一名儿童智力发育迟缓。提示这些异常可能与母亲在妊娠头三个月接受口服抗凝治疗有关。
