Meyers E F
Arch Ophthalmol. 1980 May;98(5):842-3. doi: 10.1001/archopht.1980.01020030836006.
Toxic effects were observed in two healthy patients who received cocaine intranasally before dacryocystorhinostomy. One patient suffered an additional reaction to intranasally administered phenylephrine (Neo-Synephrine) hydrochloride. Because cocaine blocks uptake of catecholamines and has a sympathetic potentiating effect, its use is dangerous in patients with hypertensive cardiovascular disease or in conjunction with sympathomimetic or alpha-modifying drugs. Use of dilute solutions carefully measured for select patients is mandatory. The total dose of cocaine should not exceed 3 mg/kg.
在两名健康患者行泪囊鼻腔吻合术前经鼻给予可卡因后观察到毒性作用。一名患者对经鼻给予的盐酸去氧肾上腺素（新福林）有额外反应。由于可卡因会阻断儿茶酚胺的摄取并具有交感神经增强作用，因此在患有高血压心血管疾病的患者中或与拟交感神经药或α-修饰药物联合使用时，其使用是危险的。必须为特定患者仔细测量并使用稀释溶液。可卡因的总剂量不应超过3mg/kg。
