• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

醋丁洛尔和双醋洛尔在人体中的血浆蛋白结合情况。

Blood plasma binding of acebutolol and diacetolol in man.

作者信息

Coombs T J, Coulson C J, Smith V J

出版信息

Br J Clin Pharmacol. 1980 Apr;9(4):395-7. doi: 10.1111/j.1365-2125.1980.tb01067.x.

DOI:10.1111/j.1365-2125.1980.tb01067.x
PMID:7378256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429991/
Abstract

1 Acebutolol or diacetolol were added to fresh human plasma in varying concentrations and their extent of binding at 25 degrees C measureed by an equilibrium dialysis technique. 2 The extent of binding for both compounds was shown to be very low, being 11-19% for acebutolol and 6-9% for diacetolol. 3 Partition coefficients were measured in an n- octanol/phosphate buffer (0.05M, pH 7.4) solvent system. For a cebutolol, P = 0.62 and for diacetol, P = 0.08. 4 The very low plasma binding is in accord with the hydrophilic partition coefficients of these compounds.

摘要
  1. 将醋丁洛尔或双醋洛尔以不同浓度添加到新鲜人血浆中，并通过平衡透析技术测定它们在25℃时的结合程度。2. 结果表明，两种化合物的结合程度都非常低，醋丁洛尔为11 - 19%，双醋洛尔为6 - 9%。3. 在正辛醇/磷酸盐缓冲液（0.05M，pH 7.4）溶剂系统中测量分配系数。醋丁洛尔的P = 0.62，双醋洛尔的P = 0.08。4. 极低的血浆结合与这些化合物的亲水性分配系数一致。

相似文献

1
Blood plasma binding of acebutolol and diacetolol in man.醋丁洛尔和双醋洛尔在人体中的血浆蛋白结合情况。
Br J Clin Pharmacol. 1980 Apr;9(4):395-7. doi: 10.1111/j.1365-2125.1980.tb01067.x.
2
[Acebutolol and diacetolol: their binding to plasma proteins and erythrocytes and secretion with the saliva].醋丁洛尔和双醋洛尔：它们与血浆蛋白及红细胞的结合以及随唾液的分泌
Farmakol Toksikol. 1991 Jan-Feb;54(1):53-5.
3
Observations on the clinical pharmacology and plasma concentrations of diacetolol, the major human metabolite of acebutolol.醋丁洛尔的主要人体代谢物双醋洛尔的临床药理学及血药浓度观察
Br J Clin Pharmacol. 1981 Oct;12(4):561-5. doi: 10.1111/j.1365-2125.1981.tb01265.x.
4
Acebutolol and diacetolol plasma levels in patients undergoing myocardial revascularization with hypothermic cardiopulmonary bypass.接受低温体外循环心肌血运重建术患者的醋丁洛尔和双醋洛尔血浆水平。
J Cardiothorac Anesth. 1990 Oct;4(5):577-81. doi: 10.1016/0888-6296(90)90407-7.
5
The beta-blocking effect of diacetolol in humans and its relationship to plasma levels.双醋洛尔在人体中的β受体阻滞作用及其与血浆水平的关系。
Int J Clin Pharmacol Ther Toxicol. 1982 Aug;20(8):358-61.
6
In vitro studies on the pharmacological properties of diacetolol, the major metabolite of acebutolol in man.醋丁洛尔在人体中的主要代谢产物双醋洛尔药理特性的体外研究。
Arch Int Pharmacodyn Ther. 1985 Jan;273(1):4-17.
7
To nurse when receiving acebutolol: is it dangerous for the neonate?接受醋丁洛尔治疗时进行母乳喂养：对新生儿有危险吗？
Eur J Clin Pharmacol. 1986;30(6):737-9. doi: 10.1007/BF00608227.
8
Pharmacokinetics and bioavailability of diacetolol, the main metabolite of acebutolol.醋丁洛尔的主要代谢产物双醋洛尔的药代动力学和生物利用度。
Eur J Clin Pharmacol. 1981 Mar;19(4):287-92. doi: 10.1007/BF00562806.
9
A pharmacokinetic study of acebutolol in aged subjects as compared to young subjects.醋丁洛尔在老年受试者与年轻受试者中的药代动力学研究。
Gerontology. 1983;29(3):202-8. doi: 10.1159/000213115.
10
Pharmacokinetics of acebutolol and its main metabolite, diacetolol after oral administration of acebutolol in rabbits with carbon tetrachloride-induced hepatic failure.醋丁洛尔及其主要代谢产物双醋洛尔在四氯化碳诱导的肝衰竭家兔口服醋丁洛尔后的药代动力学。
Arch Pharm Res. 2002 Aug;25(4):541-5. doi: 10.1007/BF02976615.

引用本文的文献

1
The penetration of acebutolol and its major metabolite, diacetolol, into human cerebrospinal fluid and saliva.醋丁洛尔及其主要代谢物双醋洛尔在人脑脊液和唾液中的渗透情况。
Br J Clin Pharmacol. 1981 Sep;12(3):427-9. doi: 10.1111/j.1365-2125.1981.tb01239.x.
2
Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man.人体内β-肾上腺素受体阻滞剂的结构与药代动力学之间的定量关系。
J Pharmacokinet Biopharm. 1984 Jun;12(3):263-87. doi: 10.1007/BF01061721.
3
Acebutolol. A review of its pharmacological properties and therapeutic efficacy in hypertension, angina pectoris and arrhythmia.醋丁洛尔。其药理学特性及在高血压、心绞痛和心律失常治疗中的疗效综述。
Drugs. 1985 Jun;29(6):531-69. doi: 10.2165/00003495-198529060-00003.
4
Clinical pharmacokinetics of beta-adrenoceptor antagonists. An update.β-肾上腺素能受体拮抗剂的临床药代动力学。最新进展。
Clin Pharmacokinet. 1987 May;12(5):305-20. doi: 10.2165/00003088-198712050-00001.
5
Effect of adjuvant arthritis on the disposition of acebutolol enantiomers in rats.佐剂性关节炎对大鼠醋丁洛尔对映体处置的影响。
Agents Actions. 1992 Nov;37(3-4):290-6. doi: 10.1007/BF02028122.

本文引用的文献

1
Influence of binding on the toxicity of bilirubin.结合作用对胆红素毒性的影响。
Ann N Y Acad Sci. 1973 Nov 26;226:225-37. doi: 10.1111/j.1749-6632.1973.tb20484.x.
2
Binding of adrenergic beta-receptor antagonists to human serum albumin.肾上腺素能β受体拮抗剂与人血清白蛋白的结合
Acta Pharm Suec. 1974 Sep;11(4):325-32.
3
Drug-albumin binding.药物-白蛋白结合
Biochem Soc Trans. 1975;3(5):635-40. doi: 10.1042/bst0030635.
4
Quantitation in plasma and urine of acebutolol and a major metabolite with preliminary observations on their disposition kinetics in man.醋丁洛尔及其主要代谢产物在血浆和尿液中的定量分析以及对其在人体处置动力学的初步观察。
Res Commun Chem Pathol Pharmacol. 1976 Sep;15(1):31-51.
5
Acebutolol disposition after intravenous administration.静脉注射后醋丁洛尔的处置情况。
Clin Pharmacol Ther. 1977 Nov;22(5 Pt 1):557-67. doi: 10.1002/cpt1977225part1557.
6
Equilibrium dialysis: a new approach.平衡透析：一种新方法。
Biochem Soc Trans. 1978;6(5):1048-50. doi: 10.1042/bst0061048.
7
Evaluation of methods to determine protein-binding of drugs. Equilibrium dialysis, ultrafiltration, ultracentrifugation, gel filtration.药物蛋白结合测定方法的评估。平衡透析、超滤、超速离心、凝胶过滤。
Arzneimittelforschung. 1977 Jul;27(7):1373-80.
8
A randomized crossover comparison of acebutolol and methyldopa in the treatment of mild to moderate essential hypertension.
Curr Med Res Opin. 1978;5(9):675-81. doi: 10.1185/03007997809110206.
9
Increased plasma protein binding of propranolol and chlorpromazine mediated by disease-induced elevations of plasma alpha1 acid glycoprotein.
N Engl J Med. 1978 Dec 28;299(26):1435-9. doi: 10.1056/NEJM197812282992604.
10
Suppression of premature ventricular contractions by acebutolol.
Circulation. 1977 May;55(5):785-91. doi: 10.1161/01.cir.55.5.785.