Edgar W, Warrell M J, Warrell D A, Prentice C R
Br J Haematol. 1980 Mar;44(3):471-81. doi: 10.1111/j.1365-2141.1980.tb05917.x.
Studies on the concentration and structure of fibrinogen, fibrinogen-fibrin soluble complexes, and fibrinogen-fibrin degradation products were made on 11 patients in Nigeria who suffered defibrination following Echis carinatus bite. Following admission, before treatment with antivenom, all patients had reduced or zero fibrinogen levels, and increased concentrations of soluble complexes and degradation products. The fibrin component of the soluble complexes, separated by fibrinogen-sepharose chromatography, consisted of both intact fibrin and fibrin degraded at the alpha-chain. After isolation by Biogel chromatography the soluble complexes were also found to contain gamma-dimer chains. The fibrinogen-fibrin degradation products consisted of several X species, Y, D and D-dimer, as well as fragment E. The major fragment in all patients was D, but a few samples contained significant quantities of D-dimer, indicating in vivo activation of factor XIII. There was evidence of degraded fibrinogen, as well as fibrin, in the soluble complexes and degradation products, suggesting that fibrinogenolysis, in addition to fibrinolysis, had occurred, probably as a result of secondary endogenous activation of the fibrinolytic system in response to defibrination.
对11名在尼日利亚被锯鳞蝰咬伤后发生去纤维蛋白化的患者的纤维蛋白原、纤维蛋白原-纤维蛋白可溶性复合物以及纤维蛋白原-纤维蛋白降解产物的浓度和结构进行了研究。入院后，在使用抗蛇毒血清治疗前，所有患者的纤维蛋白原水平均降低或为零，可溶性复合物和降解产物的浓度增加。通过纤维蛋白原-琼脂糖凝胶层析分离出的可溶性复合物中的纤维蛋白成分，既包含完整的纤维蛋白，也包含α链降解的纤维蛋白。通过凝胶过滤层析分离后，还发现可溶性复合物中含有γ-二聚体链。纤维蛋白原-纤维蛋白降解产物包括几种X片段、Y片段、D片段和D-二聚体，以及E片段。所有患者中的主要片段是D片段，但有少数样本含有大量的D-二聚体，表明体内因子XIII被激活。在可溶性复合物和降解产物中存在纤维蛋白原以及纤维蛋白降解的证据，这表明除了纤维蛋白溶解外，还发生了纤维蛋白原溶解，这可能是由于去纤维蛋白化后内源性纤溶系统的二次激活所致。
