Hunt D M, Higgs D R, Clegg J B, Weatherball D J, Marsh G W
Br J Haematol. 1980 May;45(1):53-64. doi: 10.1111/j.1365-2141.1980.tb03810.x.
The possibility of using alpha/beta globin messenger RNA (mRNA) ratios to distinguish between the carrier states for different forms of alpha thalassaemia has been explored. Alpha/beta globin mRNA ratios were determined in the red cells of a series of normal individuals and in members of four Cypriot families, one Thai and one Chinese family in which at least one person has haemoglobin H disease. It was found that there was a clear distinction in the ratios between normals, alpha thalassaemia 1 carriers, alpha thalassaemia 2 carriers, and those with haemoglobin H disease. This method should be a valuable addition to haematological analysis, haemoglobin synthesis and restriction mapping of DNA for the further elucidation of the genetics of alpha thalassaemia.
研究了利用α/β珠蛋白信使核糖核酸（mRNA）比率来区分不同形式α地中海贫血携带者状态的可能性。测定了一系列正常个体以及四个塞浦路斯家庭、一个泰国家庭和一个中国家庭成员红细胞中的α/β珠蛋白mRNA比率，这些家庭中至少有一人患有血红蛋白H病。结果发现，正常个体、α地中海贫血1携带者、α地中海贫血2携带者以及血红蛋白H病患者之间的比率存在明显差异。该方法对于血液学分析、血红蛋白合成及DNA限制性图谱分析而言应是一项有价值的补充，有助于进一步阐明α地中海贫血的遗传学机制。
