原弹性蛋白重复肽段的15N核磁共振。四肽。

15N-NMR of repeat peptides of tropoelastin. The tetrapeptide.

作者信息

Khaled M A, Okamoto K, Urry D W

出版信息

Biochim Biophys Acta. 1980 May 29;623(1):229-33. doi: 10.1016/0005-2795(80)90025-2.

DOI:10.1016/0005-2795(80)90025-2

Abstract

The 15N-NMR data obtained in chloroform and methanol are reported for Boc-L-Val1-L-Pro2-Gly3-Gly4-OMe, a repeat tetrapeptide sequence of tropoelastin. Deuterium substitution for labile peptide protons was carried out to delineate solvent-exposed and solvent-shielded peptide nitrogens. Solvent perturbation of the peptide nitrogen resonances together with the hydrogen-deuterium substitution reaffirms the previously derived conformation of the molecule in chloroform which contains a beta-turn (type II) and a 14-membered hydrogen bond to form a cross-beta structure.

摘要

报道了在氯仿和甲醇中获得的Boc-L-Val1-L-Pro2-Gly3-Gly4-OMe（原弹性蛋白的重复四肽序列）的15N-NMR数据。对不稳定的肽质子进行氘代，以区分溶剂暴露和溶剂屏蔽的肽氮。肽氮共振的溶剂扰动以及氢-氘取代再次证实了该分子在氯仿中先前推导的构象，其中包含一个β-转角（II型）和一个14元氢键以形成交叉β结构。

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