von Knorring L, Perris C, Ross S B
Biol Psychiatry. 1980 Jun;15(3):397-406.
In 84 consecutively admitted inpatients, as well as in 7 healthy volunteers, visual evoked potential to stimuli of varying intensities and serum DBH activity were determined. Patients with an augmenting (Aug.) response, i.e., a tendency to enlarge the perception of stimulation, were found to have the lowest serum DBH activities. As Aug. patients have earlier been shown to have low levels of HVA in CSF, indicating a low turnover in the dopaminergic systems in the CNS, the results indicate that the genetic factor determining the serum DBH activity may in some way also reflect the dopaminergic turnover in CNS.
对84例连续收治的住院患者以及7名健康志愿者，测定了其对不同强度刺激的视觉诱发电位和血清多巴胺β-羟化酶（DBH）活性。发现有增强（Aug.）反应的患者，即有扩大刺激感知倾向的患者，其血清DBH活性最低。由于此前已表明Aug.患者脑脊液中高香草酸（HVA）水平较低，这表明中枢神经系统（CNS）多巴胺能系统的更新率较低，因此结果表明，决定血清DBH活性的遗传因素可能在某种程度上也反映了CNS中的多巴胺能更新率。
