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水蛭Retzius神经元上谷氨酸兴奋性受体的构效关系研究。

Structure-activity studies on an excitatory receptor for glutamate on leech Retzius neurones.

作者信息

James V A, Walker R J, Wheal H V

出版信息

Br J Pharmacol. 1980 Apr;68(4):711-7. doi: 10.1111/j.1476-5381.1980.tb10864.x.

DOI:10.1111/j.1476-5381.1980.tb10864.x
PMID:7378644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044237/
Abstract

1 Intracellular recordings were made from Retzius cells from the segmental ganglia of Hirudo medicinalis and Haemopis sanguisuga. Glutamate had a direct excitatory effect on the leech Retzius cells. 2 L-Glutamate was 25 times more potent than D-glutamate. 3 L-Glutamate was approximately equipotent with ibotenic acid and 11.2 times more potent than L-aspartic acid. 4 Quisqualic acid and kainic acid were both approximately 100 times more potent than L-glutamate. DL-1-Amino-cis-1-3-dicarboxyclyclopentane was approximately 5 times more potent than L-glutamate, while the trans isomer was 105 times less potent. 5 alpha-NH2-pimelic acid and beta-CH3-glutamic acid reduced the response to L-glutamate. 6 It is suggested that glutamic acid may interact with the Retzius cell glutamate receptor in an extended conformation.

摘要
  1. 从医用水蛭和红蛭的节段神经节中的雷丘斯细胞进行细胞内记录。谷氨酸对水蛭雷丘斯细胞有直接兴奋作用。2. L-谷氨酸的效力比D-谷氨酸强25倍。3. L-谷氨酸与鹅膏蕈氨酸效力大致相当，比L-天冬氨酸强11.2倍。4. quisqualic酸和海人藻酸的效力均比L-谷氨酸强约100倍。DL-1-氨基-顺-1,3-二羧基环戊烷的效力比L-谷氨酸强约5倍，而反式异构体的效力则弱105倍。5. α-氨基庚二酸和β-甲基谷氨酸降低了对L-谷氨酸的反应。6. 提示谷氨酸可能以伸展构象与雷丘斯细胞谷氨酸受体相互作用。

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1
Structure-activity studies on an excitatory receptor for glutamate on leech Retzius neurones.水蛭Retzius神经元上谷氨酸兴奋性受体的构效关系研究。
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2
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ACS Chem Neurosci. 2013 Apr 17;4(4):635-44. doi: 10.1021/cn3002398. Epub 2013 Feb 12.
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Invert Neurosci. 2009 Mar;9(1):11-20. doi: 10.1007/s10158-008-0085-3. Epub 2009 Jan 14.
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Glutamate as a transmitter in the sensory pathway from prostomial lip to serotonergic Retzius neurons in the medicinal leech Hirudo.谷氨酸作为从药用水蛭（医蛭）的口前叶唇部到5-羟色胺能雷悌氏神经元的感觉通路中的一种神经递质。
Invert Neurosci. 1996 Sep;2(2):121-8. doi: 10.1007/BF02214115.
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Br J Pharmacol. 1985 Nov;86(3):645-54. doi: 10.1111/j.1476-5381.1985.tb08941.x.

本文引用的文献

1
EXTRACELLULAR SPACE AS A PATHWAY FOR EXCHANGE BETWEEN BLOOD AND NEURONS IN THE CENTRAL NERVOUS SYSTEM OF THE LEECH: IONIC COMPOSITION OF GLIAL CELLS AND NEURONS.水蛭中枢神经系统中细胞外空间作为血液与神经元之间交换的途径：神经胶质细胞和神经元的离子组成
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THE EFFECT ON CRAYFISH MUSCLE OF IONTOPHORETICALLY APPLIED GLUTAMATE.离子电渗法施加谷氨酸对小龙虾肌肉的影响
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Crayfish vas deferens: contractions in response to L-glutamate and gamma-aminobutyrate.小龙虾输精管：对L-谷氨酸和γ-氨基丁酸的反应性收缩
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Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid.L-谷氨酸构象受限类似物对脊髓中间神经元的兴奋作用。
Nature. 1974 Apr 26;248(5451):804-5. doi: 10.1038/248804a0.
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Glutamate antagonists at a crayfish neuromuscular junction.小龙虾神经肌肉接头处的谷氨酸拮抗剂。
Nature. 1974 Apr 5;248(448):533-5. doi: 10.1038/248533a0.
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The site of action of ibotenic acid and the identification of two populations of glutamate receptors on insect muscle-fibres.鹅膏蕈氨酸的作用位点以及昆虫肌纤维上两类谷氨酸受体的鉴定。
Comp Gen Pharmacol. 1973 Dec;4(16):333-50. doi: 10.1016/0010-4035(73)90045-1.
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A new potent excitant, quisqualic acid: effects on crayfish neuromuscular junction.一种新的强效兴奋剂——喹啉酸：对小龙虾神经肌肉接头的影响。
Neuropharmacology. 1974 Jul;13(7):665-72. doi: 10.1016/0028-3908(74)90056-2.
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Chemical transmission in invertebrate central nervous systems and neuromuscular junctions.无脊椎动物中枢神经系统和神经肌肉接头中的化学传递。
Physiol Rev. 1973 Jan;53(1):1-119. doi: 10.1152/physrev.1973.53.1.1.
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Pharmacological studies on a locust neuromuscular preparation.蝗虫神经肌肉标本的药理学研究。
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