Ribak C E, Vaughn J E, Roberts E
Brain Res. 1980 Jun 23;192(2):413-20. doi: 10.1016/0006-8993(80)90893-8.
Glutamic acid decarboxylase (GAD), the enzyme that synthesizes the neurotransmitter, GABA, was immunocytochemically localized in axon terminals as well as in small and medium-sized neurons of the rat substantia nigra. The pattern formed by GAD-containing axon terminals with the dendrites and somata of neurons in the substantia nigra was altered following ipsilateral hemitransections of the striatonigral and pallidonigral pathways. A marked reduction of GAD-positive terminals occurred throughout this brain region, but the ventral fifth of the pars reticulata showed a nearly normal pattern of GAD-positive axon terminals. The results of this investigation are consistent with results from biochemical studies which have indicated that the striatonigral and/or pallidonigral pathways are GABAergic. In addition, these results suggest that the residual GABAergic terminals remaining after hemitransection are derived from intrinsic neurons of the substantia nigra.
谷氨酸脱羧酶（GAD）是合成神经递质γ-氨基丁酸（GABA）的酶，经免疫细胞化学方法定位发现，它存在于大鼠黑质的轴突终末以及中小型神经元中。在纹状体黑质和苍白球黑质通路进行同侧半横断后，黑质中含GAD的轴突终末与神经元树突和胞体形成的模式发生了改变。在整个脑区，GAD阳性终末显著减少，但网状部腹侧五分之一区域的GAD阳性轴突终末模式几乎正常。本研究结果与生化研究结果一致，生化研究表明纹状体黑质和/或苍白球黑质通路是γ-氨基丁酸能的。此外，这些结果表明，半横断后残留的γ-氨基丁酸能终末来源于黑质的固有神经元。
