人体中安替比林的代谢：用气相色谱法同时测定尿液中的去甲安替比林和4-羟基安替比林
Antipyrine metabolism in man: simultaneous determination of norantipyrine and 4-hydroxyantipyrine in urine by gas chromatography.
作者信息
Inaba T, Fischer N E
出版信息
Can J Physiol Pharmacol. 1980 Jan;58(1):17-21. doi: 10.1139/y80-004.
DOI:10.1139/y80-004
PMID:7378903
Abstract
A gas chromatographic method was developed to determine metabolites of antipyrine, norantipyhis method requires no derivatization and has ample sensitivity to determine these metabolites in urine after ingestion of antipyrine, a compound widely used as a hepatic probe of drug oxidation.
摘要
已开发出一种气相色谱法来测定安替比林的代谢产物，诺安替比林。该方法无需衍生化，并且在摄入安替比林（一种广泛用作药物氧化肝脏探针的化合物）后，对测定尿液中的这些代谢产物具有足够的灵敏度。
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Antipyrine metabolism in man: simultaneous determination of norantipyrine and 4-hydroxyantipyrine in urine by gas chromatography.人体中安替比林的代谢：用气相色谱法同时测定尿液中的去甲安替比林和4-羟基安替比林
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引用本文的文献
1
Preparative isolation and purification of urinary conjugates in antipyrine metabolism in man and rat.
Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(3):226-33. doi: 10.1007/BF00505491.
2
Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins.安替比林代谢产物形成速率的基因变异：一项针对未诱导双胞胎的研究。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5193-6. doi: 10.1073/pnas.78.8.5193.
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