Swamy V C, Triggle D J
Can J Physiol Pharmacol. 1980 Jan;58(1):53-9. doi: 10.1139/y80-010.
The responses to noradrenaline (NA) and KCl of carotid arterial strips from spontaneously hypertensive rats (SHR) and three strains of normotensive rats (NR) were compared using tissue obtained from young (5--7 weeks) or older (15--17 weeks) rats. The maximum responses and sensitivity of strips from SHR were less than those of NR in both age groups. Relaxation of maximum NA-induced responses was consistently faster, and relaxation of KCl-induced responses generally slower with strips from SHR. Carotid strips from young SHR showed a greater dependence on extracellular calcium in their responses to NA and a lesser dependence in their KCl-induced responses than tissues from NR. We conclude that the smooth muscle of carotid arteries from SHR differs intrinsically from that of NR and that the differences in vascular responses may be related to altered excitation-contraction processes in the SHR.
使用从年轻（5 - 7周）或年长（15 - 17周）大鼠获取的组织，比较了自发性高血压大鼠（SHR）和三种正常血压大鼠（NR）品系的颈动脉条对去甲肾上腺素（NA）和氯化钾（KCl）的反应。在两个年龄组中，SHR的颈动脉条的最大反应和敏感性均低于NR。SHR的颈动脉条对最大NA诱导反应的舒张始终更快，而对KCl诱导反应的舒张通常更慢。与NR的组织相比，年轻SHR的颈动脉条在对NA的反应中对细胞外钙的依赖性更大，而在对KCl诱导反应中的依赖性较小。我们得出结论，SHR颈动脉的平滑肌在本质上与NR不同，并且血管反应的差异可能与SHR中兴奋 - 收缩过程的改变有关。
