Swamy V C, Triggle D J
Blood Vessels. 1980;17(5):246-56. doi: 10.1159/000158254.
Comparison of responses to norepinephrine (NE) and KCl of iliac arterial strips from spontaneously hypertensive rats (SHR) and three strains of normotensive rats (NR) were made in tissues obtained from 5- to 7- and 15- to 17-week-old animals. The systolic blood pressures of young rats were essentially similar while the 15- to 17-week-old SHR had markedly higher blood pressures than their normotensive counterparts. The contractility and sensitivity of strips to NE from SHR were less than those from NR in both age groups. Relaxation of NE-induced responses in normal physiological or calcium-free solutions was consistently more rapid with SHR tissues. In calcium-free solution, the fast component of responses to NE was smaller in young SHR; no difference in dependence on calcium was seen in tissues from older rats. Differences in KCl-induced responses were seen only in young animals, where reduced contractility and slower relaxation in normal physiological solutions were obtained with strips from SHR. We conclude that the iliac artery from SHR differs intrinsically from those of NR since the differences in responses were evident in young rats prior to the development of stable hypertensive state in the SHR.
对5至7周龄和15至17周龄的自发性高血压大鼠（SHR）及三种正常血压大鼠（NR）品系的髂动脉条对去甲肾上腺素（NE）和氯化钾（KCl）的反应进行了比较。幼龄大鼠的收缩压基本相似，而15至17周龄的SHR血压明显高于其正常血压的同龄大鼠。在两个年龄组中，SHR动脉条对NE的收缩性和敏感性均低于NR。在正常生理溶液或无钙溶液中，SHR组织对NE诱导反应的舒张始终更快。在无钙溶液中，幼龄SHR对NE反应的快速成分较小；老龄大鼠组织在对钙的依赖性方面未见差异。KCl诱导反应的差异仅在幼龄动物中可见，SHR的动脉条在正常生理溶液中收缩性降低且舒张较慢。我们得出结论，SHR的髂动脉与NR的髂动脉在本质上不同，因为在SHR出现稳定高血压状态之前，幼龄大鼠的反应差异就已明显。
