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不同阿片类激动剂对促黑素释放的影响：体内和体外研究

Effects of different opiate agonists on melanocyte-stimulating hormone release: in vivo and in vitro studies.

作者信息

Celis M E

出版信息

Can J Physiol Pharmacol. 1980 Mar;58(3):326-9. doi: 10.1139/y80-057.

DOI:10.1139/y80-057
PMID:7378936
Abstract

The effects of Leu-enkephalin, Met-enkephalin, and beta-endorphin on melanocyte-stimulating hormone (MSH) secretion were studied in vivo and in vitro. The three opioid peptides release MSH. In vitro this reslease is dose dependent for Met-enkephalin between 10 and 1000 ng/mL and for Leu-enkephalin between 10 and 100 ng/mL. beta-Endorphin releases MSH at the low concentration of 1 ng/mL and the effect is dose dependent between 1 and 100 ng/mL. Naloxone reverses this effect. In vivo the three petptides release MSH.

摘要

研究了亮氨酸脑啡肽、甲硫氨酸脑啡肽和β-内啡肽对促黑素细胞激素（MSH）分泌的体内和体外作用。这三种阿片肽可释放MSH。在体外，甲硫氨酸脑啡肽在10至1000 ng/mL之间、亮氨酸脑啡肽在10至100 ng/mL之间时，这种释放呈剂量依赖性。β-内啡肽在1 ng/mL的低浓度时即可释放MSH，且在1至100 ng/mL之间其作用呈剂量依赖性。纳洛酮可逆转这种作用。在体内，这三种肽均可释放MSH。

相似文献

1
Effects of different opiate agonists on melanocyte-stimulating hormone release: in vivo and in vitro studies.不同阿片类激动剂对促黑素释放的影响：体内和体外研究
Can J Physiol Pharmacol. 1980 Mar;58(3):326-9. doi: 10.1139/y80-057.
2
Interaction of beta-endorphin, naloxone and dopamine: effects on melanocyte-stimulating hormone secretion of amphibian pituitaries in vitro.β-内啡肽、纳洛酮与多巴胺的相互作用：对体外培养的两栖类垂体促黑素细胞激素分泌的影响
Regul Pept. 1982 May;3(5-6):371-81. doi: 10.1016/0167-0115(82)90060-x.
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The effect of gamma-type endorphins on alpha-MSH release in the rat.γ型内啡肽对大鼠α-促黑素细胞激素释放的影响。
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Modulation by Leu-enkephalin of peptide release from perifused neurointermediate pituitary. II. Inhibition of calcium-mediated secretion of alpha-MSH and beta-endorphin.亮脑啡肽对灌流神经垂体中间部肽释放的调节作用。II. 对钙介导的α-促黑素细胞激素和β-内啡肽分泌的抑制作用
Neuroendocrinology. 1986;42(3):248-54. doi: 10.1159/000124447.
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In vitro study of frog (Rana ridibunda Pallas) neurointermediate lobe secretion by use of a simplified perifusion system. III. Effect of neuropeptides on alpha-MSH secretion.使用简化的灌流系统对青蛙（泽蛙，帕拉斯）神经中间叶分泌进行的体外研究。III. 神经肽对α-促黑素细胞激素分泌的影响。
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Differences in the release of melanocyte-stimulating hormone in vitro by rat pituitary glands collected at various times during the oestrous cycle.
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Opiate receptors influence vasopressin release from nerve terminals in rat neurohypophysis.阿片受体影响大鼠神经垂体神经末梢中血管加压素的释放。
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Naunyn Schmiedebergs Arch Pharmacol. 1984 Dec;328(2):191-5. doi: 10.1007/BF00512071.
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Interaction of alpha-melanocyte-stimulating hormone with beta-endorphin to influence anterior pituitary hormone secretion in the female rat.α-黑素细胞刺激素与β-内啡肽相互作用对雌性大鼠垂体前叶激素分泌的影响。
Endocrinology. 1986 Sep;119(3):1071-5. doi: 10.1210/endo-119-3-1071.

引用本文的文献

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Effects of acute opiate-peptide administration on pro-opiomelanocortin cells of the intermediate lobe of the rat pituitary.急性给予阿片肽对大鼠垂体中间叶促阿片黑素细胞皮质素原细胞的影响。
Cell Tissue Res. 1982;225(1):217-22. doi: 10.1007/BF00216230.