由于苯妥英钠，小鼠体内免疫球蛋白浓度降低且巨噬细胞功能受损。
Reduced immunoglobulin concentration and impaired macrophage function in mice due to diphenylhydantoin.
作者信息
Seager J, Coovadia H M, Soothill J F
出版信息
Clin Exp Immunol. 1978 Sep;33(3):437-40.
Abstract
Diphenylhydantoin (DPH) depresses serum IgA and IgM concentrations and polyvinyl pyrrolidone (PVP) clearance in mice.
摘要
二苯乙内酰脲（DPH）可降低小鼠血清中IgA和IgM的浓度以及聚乙烯吡咯烷酮（PVP）的清除率。
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本文引用的文献
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QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES.抗体琼脂平板中血清免疫球蛋白的定量测定
J Immunol. 1965 Jan;94:84-90.
2
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4
A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector.
Clin Chim Acta. 1973 Feb 12;43(3):423-9. doi: 10.1016/0009-8981(73)90482-8.
5
Biological activities of immunoglobulins of different classes and subclasses.不同类别和亚类免疫球蛋白的生物学活性
Adv Immunol. 1974;19(0):259-94. doi: 10.1016/s0065-2776(08)60254-0.
6
7
Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration.体外免疫应答中的细胞相互作用。II. 淋巴细胞协作中巨噬细胞的需求。
J Exp Med. 1972 May 1;135(5):1049-58. doi: 10.1084/jem.135.5.1049.
8
Drug-induced IgA deficiency in epileptic patients.癫痫患者的药物性IgA缺乏症。
Arch Neurol. 1976 Apr;33(4):296-9. doi: 10.1001/archneur.1976.00500040080014.
9
Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro.苯妥英钠和卡马西平对免疫能力的抑制作用。体内和体外研究。
Clin Exp Immunol. 1975 May;20(2):273-85.
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Hydantoin immunosuppression and carcinogenesis.乙内酰脲免疫抑制作用与致癌作用。
Clin Exp Immunol. 1975 Mar;19(3):521-7.
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