血清癌胚抗原在甲状腺结节患者癌症术前诊断中的作用。

Role of serum carcinoembryonic antigen in preoperative diagnosis of cancer in patients with thyroid nodules.

作者信息

Madeddu G, Langer M, Dettori G, Costanza C

出版信息

Cancer. 1980 May 15;45(10):2607-10. doi: 10.1002/1097-0142(19800515)45:10<2607::aid-cncr2820451020>3.0.co;2-b.

DOI:10.1002/1097-0142(19800515)45:10<2607::aid-cncr2820451020>3.0.co;2-b

Abstract

Serum carcinoembryonic antigen (CEA) was measured by double antibody radioimmunoassay technique in 95 normal subjects and in 258 patients with thyroid nodules. All the normal subjects and the patients with benign nodules had normal CEA values. Increased serum CEA levels (above 50 ng/ml) were found in all medullary and undifferentiated (giant cell) carcinomas. After surgery, the CEA fell within the normal range in the patients with medullary carcinoma. High levels of CEA were also present in 26% of differentiated carcinomas. A relationship between high CEA values and the presence of metastatic disease was not found. Measurement of serum carciniembryonic antigen may be useful in the preoperative diagnosis of cancer in patients with thyroid nodules.

摘要

采用双抗体放射免疫测定技术检测了95名正常受试者和258例甲状腺结节患者的血清癌胚抗原（CEA）。所有正常受试者和良性结节患者的CEA值均正常。在所有髓样癌和未分化癌（巨细胞癌）患者中均发现血清CEA水平升高（高于50 ng/ml）。髓样癌患者术后CEA降至正常范围。26%的分化型癌患者也存在CEA高水平。未发现CEA高值与转移性疾病之间的关系。血清癌胚抗原的检测可能有助于甲状腺结节患者癌症的术前诊断。