Johnson J A, Fabri P J, Lott J A
Clin Chem. 1980 Jun;26(7):867-70.
We determined the relative concentrations of gastrin molecular species in serum samples from 21 patients with Zollinger-Ellison syndrome with localized gastrinoma (n = 11) or gastrinoma with hepatic metastases (n = 10). Gastrin molecular species were separated by gel-filtration chromatography and quantitated by radioimmunoassay with a gastrin antiserum produced in our laboratory. The percentage gastrin-17 of the total gastrin in the two groups differed significantly (nonparametric Wilcoxon rank test; p less than 0.01). Patients with the Zollinger-Ellison syndrome with apparently localized gastrinoma had a lower percentage of G- 17 (7.6%, SEM 1.6%) than did patients with gastrinoma with hepatic metastases (31.1%, SEM 6.1%). This procedure may be useful in the early classification of tumors in patients with Zollinger-Ellison syndrome.
我们测定了21例患有局限性胃泌素瘤（n = 11）或伴有肝转移的胃泌素瘤（n = 10）的佐林格-埃利森综合征患者血清样本中胃泌素分子种类的相对浓度。胃泌素分子种类通过凝胶过滤色谱法分离，并使用我们实验室制备的胃泌素抗血清通过放射免疫测定法定量。两组中胃泌素-17占总胃泌素的百分比差异显著（非参数威尔科克森秩和检验；p小于0.01）。患有明显局限性胃泌素瘤的佐林格-埃利森综合征患者的G-17百分比（7.6%，标准误1.6%）低于伴有肝转移的胃泌素瘤患者（31.1%，标准误6.1%）。该方法可能有助于佐林格-埃利森综合征患者肿瘤的早期分类。
