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多巴胺作为人体血管蛋白释放抑制剂的证据。

Evidence for dopamine as an inhibitor of vasoprotein release in man.

作者信息

Lightman S L, Forsling M

出版信息

Clin Endocrinol (Oxf). 1980 Jan;12(1):39-46. doi: 10.1111/j.1365-2265.1980.tb03130.x.

DOI:10.1111/j.1365-2265.1980.tb03130.x
PMID:7379312
Abstract

The effect of dopamine on vasopressin release was studied by the infusion of L-Dopa, a dopamine precursor that crosses the blood-brain barrier. L-Dopa suppressed resting levels of vasopressin and inhibited the rise of vasopressin produced by head-up tilt. Carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier blocked the action of L-Dopa. These results suggest that dopamine inhibits the release of vasopressin, either by an action at pituitary level or at the median eminence of the hypothalamus.

摘要

通过输注左旋多巴(一种可穿过血脑屏障的多巴胺前体),研究了多巴胺对血管加压素释放的影响。左旋多巴抑制了血管加压素的静息水平,并抑制了由头高位倾斜引起的血管加压素升高。卡比多巴是一种不能穿过血脑屏障的脱羧酶抑制剂,它阻断了左旋多巴的作用。这些结果表明,多巴胺通过作用于垂体水平或下丘脑正中隆起,抑制血管加压素的释放。

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