Cain D P
Epilepsia. 1980 Jun;21(3):243-9. doi: 10.1111/j.1528-1157.1980.tb04069.x.
The effects of either kindling or nonkindling brain stimulation on pentylenetetrazol (PTZ)-induced convulsion susceptibility was assessed, using rats. The results show that repeated brain stimulation alone is sufficient to reduce the threshold dose of PTZ required to evoke a generalized convulsion, and that kindled convulsions do not significantly reduce the threshold further. However, kindled convulsions do increase the PTZ-induced convulsion duration and severity relative to that seen in stimulated or unstimulated animals. These results suggest that the increased convulsion susceptibility has two components that depend on different aspects of brain stimulation kindling.
利用大鼠评估了点燃式或非点燃式脑刺激对戊四氮（PTZ）诱导惊厥易感性的影响。结果表明，单独重复脑刺激足以降低诱发全身性惊厥所需的PTZ阈值剂量，并且点燃式惊厥不会进一步显著降低该阈值。然而，相对于在受刺激或未受刺激的动物中观察到的情况，点燃式惊厥确实会增加PTZ诱导的惊厥持续时间和严重程度。这些结果表明，惊厥易感性增加有两个组成部分，这取决于脑刺激点燃的不同方面。
