Wiener J D
Eur J Nucl Med. 1980 Apr;5(2):119-24. doi: 10.1007/BF00252470.
Normalized T4 (T4N), total T3, T3 resin sponge uptake (T3U) and the response of TSH to TRH were determined in 264 patients sent for diagnosis of thyroid function. Many of these patients were diagnostic problem cases. Those with disease or medication known to invalidate the TRH test, but not those with abnormal thyroid hormone binding capacity in serum, were excluded. A free T3 index (FT3 index) was calculated as the product of total T3 and T3U. The FT3 index tended to decline with increasing age, the mean value being significantly higher in the youngest patients (12-20-years-old) than in the older age groups. In the diagnosis of hyperthyroidism, the FT3 index was superior not only to T4N but also to total T3, particularly in the presence of elevated hormone binding capacity (relatively low T3U). It is anticipated that the FT3 index will be most useful as a routine test for hyperthyroidism, especially in several (though not all) instances where the TRH test is invalidated.
对264例因甲状腺功能诊断而前来就诊的患者测定了标准化T4（T4N）、总T3、T3树脂摄取率（T3U）以及促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应。这些患者中有许多是诊断难题病例。那些患有已知会使TRH试验无效的疾病或正在服用相关药物的患者被排除，但血清甲状腺激素结合能力异常的患者未被排除。游离T3指数（FT3指数）通过总T3与T3U的乘积计算得出。FT3指数往往随着年龄增长而下降，最年轻患者（12至20岁）的平均值显著高于年龄较大的组。在甲状腺功能亢进症的诊断中，FT3指数不仅优于T4N，也优于总T3，尤其是在激素结合能力升高（T3U相对较低）的情况下。预计FT3指数作为甲状腺功能亢进症的常规检测将最为有用，特别是在TRH试验无效的几种（尽管不是所有）情况下。
