Sterling K, Bellabarba D, Newman E S, Brenner M A
J Clin Invest. 1969 Jun;48(6):1150-8. doi: 10.1172/JCI106072.
A simplified method has been described for the measurement of triiodothyronine (T3) in human serum. The sensitivity was sufficient for determinations on hypothyroid as well as normal and thyrotoxic sera. The values obtained have been in reasonable agreement with a double isotope derivative assay. The normal T3 concentration in human serum approximates 0.2 mug/100 ml; the mean +/-SD of 31 normal sera was 220 +/-27 ng/100 ml. Elevations were observed in sera from 40 patients with thyrotoxicosis (752 +/-282 ng/100 ml), and diminutions were found in sera from 10 hypothyroid patients (98+/-48 ng/100 ml). In rare instances thyrotoxicosis may be due to elevated serum T3 with normal thyroxine (T4) concentration. The incidence of this condition remains to be determined. In approximately half the cases with low serum T4 after (131)I therapy, the eumetabolic state may be maintained by normal or elevated T3 concentration. From these data and kinetic studies indicating a rapid turnover it may be inferred that T3 rather than T4 may be the more important hormone in health and in disease.
本文描述了一种用于测定人血清中三碘甲状腺原氨酸（T3）的简化方法。该方法的灵敏度足以用于测定甲状腺功能减退以及正常和甲状腺毒症患者的血清。所获得的值与双同位素衍生物测定法具有合理的一致性。人血清中正常T3浓度约为0.2μg/100ml；31份正常血清的平均值±标准差为220±27ng/100ml。在40例甲状腺毒症患者的血清中观察到T3升高（752±282ng/100ml），在10例甲状腺功能减退患者的血清中发现T3降低（98±48ng/100ml）。在罕见情况下，甲状腺毒症可能是由于血清T3升高而甲状腺素（T4）浓度正常所致。这种情况的发生率尚待确定。在约一半的（131）I治疗后血清T4降低的病例中，正常或升高的T3浓度可能维持代谢正常状态。从这些数据以及表明快速周转的动力学研究可以推断，T3而非T4可能是健康和疾病中更重要的激素。
