Sietnieks A, Meyerson B J
Eur J Pharmacol. 1980 Apr 11;63(1):57-64. doi: 10.1016/0014-2999(80)90116-8.
Copulatory behavior in the ovariectomized rat, the lordosis response (L.R.) was induced by either estrogen alone or estrogen followed by progesterone. L.R. has been shown to be inhibited dose-dependently by lysergic acid diethylamide (LSD). The effects of various hormone treatments on the LSD-induced inhibition were tested in the present study. Progesterone but not estrogen was found to significantly enhance the LSD effect in a dose-dependent manner. In contrast, the effect of LSD on spontaneous behaviors in an exploratory situation was not influenced by progesterone treatment. This phenomenon of increased L.R. inhibitor effect by LSD was probably not due to a steroid-induced change in LSD metabolism. The data show instead that progesterone specifically influences monoaminergic mechanisms, which are related to the action of LSD. This has important implications for the possibility that progesterone induces the L.R. by acting on monoaminergic mechanisms.
在去卵巢大鼠的交配行为中，弓背反应（L.R.）可由单独的雌激素或雌激素后接孕酮诱导产生。已表明L.R.会被麦角酸二乙酰胺（LSD）剂量依赖性地抑制。在本研究中测试了各种激素处理对LSD诱导抑制的影响。发现孕酮而非雌激素以剂量依赖性方式显著增强LSD效应。相比之下，LSD对探索情境中自发行为的影响不受孕酮处理的影响。LSD增强L.R.抑制效应的这种现象可能并非由于类固醇诱导的LSD代谢变化。相反，数据表明孕酮特异性地影响与LSD作用相关的单胺能机制。这对于孕酮通过作用于单胺能机制诱导L.R.的可能性具有重要意义。
