Alexander N, Haun C K
Eur J Pharmacol. 1980 May 2;63(2-3):117-25. doi: 10.1016/0014-2999(80)90435-5.
The characteristic movement-related arterial pressure dips seen in sinoaortic-denervated (SAD) animals suggested they should have enhanced vasodepressor responses to central adrenergic agonists. This was tested by comparing the reductions in mean arterial pressure and heart rate of conscious sham-operated (SO) and SAD rats during injections of norepinephrine (NE) or epinephrine (E) (0.25--16 micrograms) into the fourth cerebral ventricle. NE produced significantly greater maximum vasodepression and, simultaneously, significantly less bradycardia in SAD than SO rats. E, like NE, produced significantly more vasodepression in SADs, but unlike NE, elicited the same magnitude of bradycardia in both groups. The pressures were reduced and the log-dose pressure response curves shifted to the left in SAD rats. These results provide indirect evidence that central sensitivity to intracerebroventricular catecholamines is altered in SAD rats and that the direction of change in sensitivity is divergent for pressure and heart rate.
在去窦主动脉神经（SAD）动物中观察到的与运动相关的特征性动脉压下降表明，它们对中枢肾上腺素能激动剂的血管减压反应应该增强。通过比较清醒的假手术（SO）大鼠和SAD大鼠在向第四脑室注射去甲肾上腺素（NE）或肾上腺素（E）（0.25 - 16微克）期间平均动脉压和心率的降低情况来进行测试。与SO大鼠相比，NE在SAD大鼠中产生的最大血管减压作用明显更大，同时心动过缓明显更少。E与NE一样，在SAD大鼠中产生的血管减压作用明显更多，但与NE不同的是，两组中引起的心动过缓程度相同。SAD大鼠的血压降低，对数剂量 - 压力反应曲线向左移动。这些结果提供了间接证据，表明SAD大鼠对脑室内儿茶酚胺的中枢敏感性发生了改变，并且敏感性变化的方向在压力和心率方面是不同的。
