Su D F, Yang Y C, Xie J E
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Eur J Pharmacol. 1992 Apr 7;214(1):89-91. doi: 10.1016/0014-2999(92)90101-9.
The effects of ketanserin on blood pressure and heart rate were studied in sinoaortic denervated (SAD) rats. It was found that the dose-effect curves for blood pressure and heart rate were the same in anesthetized SAD and sham-operated rats. However, SAD sharpened the dose-effect curves in conscious freely moving rats. It is concluded that the lack of hypotensive effect of ketanserin in conscious normotensive animals is due in large part to the integrity of the arterial baroreflex.
在去窦主动脉神经支配（SAD）大鼠中研究了酮色林对血压和心率的影响。结果发现，麻醉的SAD大鼠和假手术大鼠的血压和心率剂量-效应曲线相同。然而，SAD使清醒自由活动大鼠的剂量-效应曲线变陡。得出的结论是，酮色林在清醒正常血压动物中缺乏降压作用在很大程度上归因于动脉压力反射的完整性。
