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Structure and toxicity of the alkaloids of Russian comfrey (symphytum x uplandicum Nyman), a medicinal herb and item of human diet.

作者信息

Culvenor C C, Clarke M, Edgar J A, Frahn J L, Jago M V, Peterson J E, Smith L W

出版信息

Experientia. 1980 Apr 15;36(4):377-9. doi: 10.1007/BF01975096.

DOI:10.1007/BF01975096
PMID:7379906
Abstract

Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves of Symphytum X uplandicum. The combined alkaloids exhibit chronic hepatotoxicity in rats.

摘要

相似文献

1
Structure and toxicity of the alkaloids of Russian comfrey (symphytum x uplandicum Nyman), a medicinal herb and item of human diet.
Experientia. 1980 Apr 15;36(4):377-9. doi: 10.1007/BF01975096.
2
Determination of pyrrolizidine alkaloids in commercial comfrey products (Symphytum sp.).市售紫草科植物产品（聚合草属）中吡咯里西啶生物碱的测定。
J Pharm Sci. 1994 May;83(5):649-53. doi: 10.1002/jps.2600830511.
3
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Phytochem Anal. 2008 Nov-Dec;19(6):526-33. doi: 10.1002/pca.1079.
4
[Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study].[聚合草提取物乳膏（聚合草杂交种 NYMAN：）的伤口愈合效果：一项随机、对照双盲研究的结果]
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5
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Regul Toxicol Pharmacol. 2020 Dec;118:104784. doi: 10.1016/j.yrtph.2020.104784. Epub 2020 Sep 15.
6
Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids.对由聚合草（药用聚合草）叶子制成的草药茶的分析：N-氧化物的减少导致可测量的吡咯里西啶生物碱浓度呈数量级增加。
Public Health Nutr. 2004 Oct;7(7):919-24. doi: 10.1079/phn2004624.
7
Studies on medicinal plants of Sri Lanka: occurrence of pyrrolizidine alkaloids and hepatotoxic properties in some traditional medicinal herbs.斯里兰卡药用植物研究：某些传统草药中吡咯里西啶生物碱的存在及其肝毒性
J Ethnopharmacol. 1981 Sep;4(2):159-77. doi: 10.1016/0378-8741(81)90033-7.
8
The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus).雏鸡（家鸡）中还原粗制聚合草（药用聚合草）生物碱提取物与纯的源自聚合草的吡咯里西啶生物碱——狼紫草胺和中草乌碱的比较毒性。
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9
The efficacy and safety of comfrey.紫草科植物的功效与安全性。
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A rapid cleanup method for the isolation and concentration of pyrrolizidine alkaloids in comfrey root.一种用于分离和浓缩紫草科植物根中吡咯里西啶生物碱的快速净化方法。
J AOAC Int. 2004 Sep-Oct;87(5):1049-57.

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Molecules. 2019 Jun 18;24(12):2272. doi: 10.3390/molecules24122272.
2
Pyrrolizidine alkaloids from Symphytum officinale L. and their percutaneous absorption in rats.
Experientia. 1982 Sep 15;38(9):1085-7. doi: 10.1007/BF01955382.
3
Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet.关于吸烟与植物性饮食的肺癌流行病学调查。

本文引用的文献

1
Liver lesions in young rats suckled by mothers treated with the pyrrolizidine (Senecio) alkaloids, lasiocarpine and retrorsine.用吡咯里西啶（千里光属）生物碱、阔叶千里光碱和倒千里光碱处理过的母鼠哺育的幼鼠肝脏损伤。
J Pathol Bacteriol. 1959 Apr;77(2):485-95. doi: 10.1002/path.1700770220.
2
Bioassay of lasiocarpine for possible carcinogenicity.对毛果天芥菜碱潜在致癌性的生物测定。
Natl Cancer Inst Carcinog Tech Rep Ser. 1978;39:1-66.
3
The photometric microdetermination of serum total globulins with a tryptophan reaction: a modified procedure.
Jpn J Cancer Res. 1989 Jun;80(6):513-20. doi: 10.1111/j.1349-7006.1989.tb01669.x.
4
The harmful potential of herbal and other plant products.草药及其他植物产品的潜在危害。
Drug Saf. 1990;5 Suppl 1:126-36. doi: 10.2165/00002018-199000051-00020.
采用色氨酸反应的血清总球蛋白光度微量测定法：一种改进方法。
Clin Chem. 1966 Jul;12(7):414-7.
4
Studies on constituents of crude drugs. I. Alkaloids of Symphytum officinale Linn.生药成分研究。I. 药用紫草的生物碱
Chem Pharm Bull (Tokyo). 1968 Dec;16(12):2512-6. doi: 10.1248/cpb.16.2512.
5
[Recommendations of the German Society for Clinical Chemistry. Standardization of methods for the determination of enzyme activities in biological fluids].[德国临床化学学会的建议。生物体液中酶活性测定方法的标准化]
Z Klin Chem Klin Biochem. 1970 Nov;8(6):658-60.
6
A method for the assessment of the chronic hepatoxicity of pyrrolizidine alkaloids.一种评估吡咯里西啶生物碱慢性肝毒性的方法。
Aust J Exp Biol Med Sci. 1970 Feb;48(1):93-103. doi: 10.1038/icb.1970.9.
7
The toxic actions of pyrrolizidine (senecio) alkaloids.
Pharmacol Rev. 1970 Dec;22(4):429-83.
8
Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L.
Cancer Res. 1970 Aug;30(8):2127-31.
9
Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.吡咯里西啶生物碱及其衍生物的肝毒性和肺毒性与分子结构的关系
Chem Biol Interact. 1976 Mar;12(3-4):299-324. doi: 10.1016/0009-2797(76)90046-6.
10
Crotalaria Retusa poisoning of pigs and poultry.猪和家禽的猪屎豆中毒
Aust Vet J. 1977 Mar;53(3):109-14. doi: 10.1111/j.1751-0813.1977.tb00129.x.