[3,4,5,6-四氢嘧啶和3,6-二氢嘧啶衍生物的毒性及辐射防护特性]
[Toxicity and radioprotective properties of 3,4,5,6-tetrahydropyrimidine and 3,6-dihydropyrimidine derivatives].
作者信息
Il'iuchenko T Iu, Frigidova L M, Shadurskiĭ K S, Lepekhin V P, Ignatova L A
出版信息
Farmakol Toksikol. 1980 Jan-Feb;43(1):103-7.
PMID:7379985
Abstract
Acute toxicity and radioprotective properties of 16 derivatives of tetrahydro- and dihydropyrimidines were studied in experiments on mice. Hydroiodides of 4,6,6-trimethyl-3,R-2-methylthio-3,6-dihydropyrimidines were shown to be more toxic than respective hydroiodides of 4,6,6-trimethyl-3-R-2-methylthio-4-oxy-3,4,5,6-tetrahydropyrimidines. Four compounds exhibited moderate radioprotective properties.
摘要
在小鼠实验中研究了16种四氢和二氢嘧啶衍生物的急性毒性和辐射防护特性。结果表明，4,6,6-三甲基-3,R-2-甲硫基-3,6-二氢嘧啶的氢碘酸盐比相应的4,6,6-三甲基-3-R-2-甲硫基-4-氧代-3,4,5,6-四氢嘧啶的氢碘酸盐毒性更大。有四种化合物表现出中等程度的辐射防护特性。
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