一种胃黏膜损伤实验研究的新方法——低氧血症大鼠胃黏膜的变化
A new method for experimental study on gastric mucosal damage--changes in gastric mucosa of rat in hypoxemia.
作者信息
Nakazawa S, Segawa K, Imai K, Aichi M, Tsukamoto Y
出版信息
Gastroenterol Jpn. 1980 Apr;15(2):173-6. doi: 10.1007/BF02774933.
PMID:7380169
Abstract
We have demonstrated development of mucosal damage in rats maintained in a hypoxic condition. The gastric lesions were observed only in the corpus ventriculi in almost all cases, and they were rated as Ul-1 erosions histopathologically. The method has proven to facilitate the induction of long-sustained, stable hypoxemia of any desired degree in animals and is concluded to be appropriate for an experimental model of ulceration designed for the study of defensive mechanisms.
摘要
我们已经证明，处于缺氧状态的大鼠会出现黏膜损伤。几乎在所有情况下，胃损伤仅在胃体部观察到，组织病理学上其被评为Ul-1级糜烂。该方法已被证明有助于在动物中诱导出任何所需程度的长期持续、稳定的低氧血症，并且得出结论，该方法适用于为研究防御机制而设计的溃疡实验模型。
Zotero 插件