Melchert F, Kreienberg R, von Nathusius U
Fortschr Med. 1980 Feb 28;98(8):281-6.
After radical mastectomy and postoperative radiotherapy 56 patients with loco-regional breast cancer and positive lymph nodes and/or tumor size over 2 cm in diameter were treated by a "mild" adjuvant chemotherapy: Cyclophosphamide 150 mg p.o./day + Methotrexate 7,5 mg on three consecutive days p.o./week. The study was started on July 1st 1975, duration of treatment was planned for two years/patient. At the time of evaluation (May 1st 1979) 21 pre- and 35 postmenopausal patients were under study. 7 patients (12,5%) recurred within 6-36 months after the beginning of chemotherapy. Two women died after 20 resp. 36 months. Median time of treatment was 19 months. Chemotherapy caused very mild toxicity and was well tolerated. Patients under adjuvant chemotherapy developed only a transitory depression of B- and T-cells as well as mitogen-induced lymphocyte stimulation whereas patients under polychemotherapy showed a marked depression of these immunological markers.
对56例局部区域性乳腺癌且淋巴结阳性和/或肿瘤直径超过2厘米的患者，在进行根治性乳房切除术后和术后放疗后，采用“温和”的辅助化疗：环磷酰胺150毫克口服/天 + 甲氨蝶呤7.5毫克，连续三天口服/周。该研究于1975年7月1日开始，计划每位患者的治疗持续两年。在评估时（1979年5月1日），有21例绝经前和35例绝经后患者正在接受研究。7例患者（12.5%）在化疗开始后的6 - 36个月内复发。两名女性分别在20个月和36个月后死亡。中位治疗时间为19个月。化疗引起的毒性非常轻微，耐受性良好。接受辅助化疗的患者仅出现B细胞和T细胞的短暂抑制以及丝裂原诱导的淋巴细胞刺激，而接受多药化疗的患者这些免疫标志物则出现明显抑制。
