Oren M E, Herberman R B
Clin Exp Immunol. 1971 Jul;9(1):45-56.
Autochthonous tumour cell membrane extracts produced delayed hypersensitivity reactions in patients with a variety of neoplastic diseases. When tested at low protein concentrations (≤0·33 mg/0·1 ml), autochthonous tumour extracts produced positive reactions in 50% of non-anergic cancer patients. The same dose of autochthonous leucocyte membranes produced a significantly lower incidence of positive reactions (10%) in normal volunteers. In contrast, the cancer patients were less reactive than the normal volunteers to a battery of standard skin test antigens. In patients with acute lymphocytic leukaemia, positive reactions were more often obtained during remission. The protein concentration of the extracts was found to be an important factor in these studies. Extracts with high protein concentrations elicited positive reactions in both the patients and in the normal volunteers. It remains to be determined whether the reactions to the high protein concentrations are due to non-specific inflammation or to a low level of autoimmunity in both patients and controls.
自体肿瘤细胞膜提取物在患有多种肿瘤疾病的患者中引发了迟发型超敏反应。当在低蛋白浓度（≤0·33毫克/0·1毫升）下进行测试时，自体肿瘤提取物在50%的非无反应性癌症患者中产生了阳性反应。相同剂量的自体白细胞膜在正常志愿者中产生阳性反应的发生率显著较低（10%）。相比之下，癌症患者对一系列标准皮肤试验抗原的反应性低于正常志愿者。在急性淋巴细胞白血病患者中，缓解期更常出现阳性反应。在这些研究中，发现提取物的蛋白浓度是一个重要因素。高蛋白浓度的提取物在患者和正常志愿者中均引发了阳性反应。高蛋白浓度引发的反应是由于非特异性炎症还是患者和对照组中低水平的自身免疫，仍有待确定。
